Cellosaurus CEM-GXR25 (CVCL_C8ZB)
Cell line name | CEM-GXR25 | |
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Synonyms | GXR; CEM-GFP, CXCR4, CCR5, clone 25 | |
Accession | CVCL_C8ZB | |
Resource Identification Initiative | To cite this cell line use: CEM-GXR25 (RRID:CVCL_C8ZB) | |
Comments | Population: Caucasian. Virology: HIV-1 infection reporter cell line, the gene for GFP is under the control of a HIV-1 long terminal repeat. Thansk to the increased expression of CCR5 can be used for both CXCR4-tropic and CCR5-tropic HIV-1 strains (PubMed=16182382). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5. Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. | |
Sequence variations |
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Disease | Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) | |
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |
Hierarchy | Parent: CVCL_1G53 (CEM-GFP) Children:
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Sex of cell | Female | |
Age at sampling | 3Y11M | |
Category | Cancer cell line | |
Publications | PubMed=16182382; DOI=10.1016/j.jviromet.2005.08.003 | |
Cross-references | ||
Encyclopedic resources | Wikidata; Q123030896 | |
Entry history | ||
Entry creation | 05-Oct-2023 | |
Last entry update | 19-Dec-2024 | |
Version number | 4 |