Cellosaurus logo
expasy logo

Cellosaurus CEM-GFP (CVCL_1G53)

[Text version]
Cell line name CEM-GFP
Accession CVCL_1G53
Resource Identification Initiative To cite this cell line use: CEM-GFP (RRID:CVCL_1G53)
Comments Population: Caucasian.
Virology: HIV-1 infection reporter cell line, the gene for GFP is under the control of a HIV-1 long terminal repeat.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_C8ZB (CEM-GXR25)
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
Publications

PubMed=9114046; DOI=10.1073/pnas.94.9.4653; PMCID=PMC20779
Gervaix A., West D., Leoni L.M., Richman D.D., Wong-Staal F., Corbeil J.
A new reporter cell line to monitor HIV infection and drug susceptibility in vitro.
Proc. Natl. Acad. Sci. U.S.A. 94:4653-4658(1997)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-3655
Cell line databases/resources cancercelllines; CVCL_1G53
Encyclopedic resources Wikidata; Q54809250
Entry history
Entry creation08-Jul-2015
Last entry update19-Dec-2024
Version number20