Cellosaurus cell line HMS50-E7-5 (CVCL

Cross-references
Cell line name	HMS50-E7-5
Accession	CVCL_C7T0
Resource Identification Initiative	To cite this cell line use: HMS50-E7-5 (RRID:CVCL_C7T0)
Comments	Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Breast, interlobular stroma; UBERON=UBERON_8480033. Cell type: Fibroblast; CL=CL_0000057.
Sequence variations	Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Thr (c.398T>C); ClinVar=VCV000012357; Zygosity=Heterozygous (PubMed=7799951).
Disease	Li-Fraumeni syndrome (NCIt: C3476) Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_C7T2 (HMS50)
Sex of cell	Female
Age at sampling	31Y
Category	Transformed cell line
Publications	PubMed=7799951; DOI=10.1128/mcb.15.1.425; PMCID=PMC231985 Shay J.W., Tomlinson G.E., Piatyszek M.A., Gollahon L.S. Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Mol. Cell. Biol. 15:425-432(1995)
Encyclopedic resources	Wikidata; Q117704496
Entry history
Entry creation	21-Mar-2023
Last entry update	19-Dec-2024
Version number	5