ID   HMS50-E7-5
AC   CVCL_C7T0
DR   Wikidata; Q117704496
RX   PubMed=7799951;
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met133Thr (c.398T>C); ClinVar=VCV000012357; Zygosity=Heterozygous (PubMed=7799951).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Breast, interlobular stroma; UBERON=UBERON_8480033.
CC   Cell type: Fibroblast; CL=CL_0000057.
DI   NCIt; C3476; Li-Fraumeni syndrome
DI   ORDO; Orphanet_524; Li-Fraumeni syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_C7T2 ! HMS50
SX   Female
AG   31Y
CA   Transformed cell line
DT   Created: 21-03-23; Last updated: 19-12-24; Version: 5
//
RX   PubMed=7799951; DOI=10.1128/mcb.15.1.425; PMCID=PMC231985;
RA   Shay J.W., Tomlinson G.E., Piatyszek M.A., Gollahon L.S.;
RT   "Spontaneous in vitro immortalization of breast epithelial cells from
RT   a patient with Li-Fraumeni syndrome.";
RL   Mol. Cell. Biol. 15:425-432(1995).
//