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Cellosaurus Jurkat B2M KO (CVCL_C3CE)

[Text version]
Cell line name Jurkat B2M KO
Accession CVCL_C3CE
Resource Identification Initiative To cite this cell line use: Jurkat B2M KO (RRID:CVCL_C3CE)
Comments Population: Caucasian.
Knockout cell: Method=ZFN; HGNC; 914; B2M.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_C3CQ (Jurkat HLA-A*01:01)CVCL_C3CR (Jurkat HLA-A*02:01)CVCL_C3CS (Jurkat HLA-A*03:01)
CVCL_C3CT (Jurkat HLA-A*11:01)CVCL_C3CU (Jurkat HLA-A*24:02)CVCL_C3CV (Jurkat HLA-B*07:02)
CVCL_C3CW (Jurkat HLA-B*08:01)CVCL_C3CX (Jurkat HLA-B*15:10)CVCL_C3CY (Jurkat HLA-B*35:01)
CVCL_C3CZ (Jurkat HLA-B*40:01)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): Sigma-Aldrich=HLA002

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S8189
D7S8208,12
D8S117913,14
D13S3178,11
D16S53911
D18S5113,22
D21S1131.2,33.2
FGA20
Penta D11,13
Penta E9,12
TH016,9.3
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Cross-references
Cell line collections (Providers) Sigma-Aldrich; HLA002
Cell line databases/resources cancercelllines; CVCL_C3CE
Encyclopedic resources Wikidata; Q114311791
Entry history
Entry creation22-Sep-2022
Last entry update10-Sep-2024
Version number6