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Cellosaurus Jurkat HLA-B*15:10 (CVCL_C3CX)

[Text version]
Cell line name Jurkat HLA-B*15:10
Accession CVCL_C3CX
Resource Identification Initiative To cite this cell line use: Jurkat HLA-B*15:10 (RRID:CVCL_C3CX)
Comments Population: Caucasian.
Characteristics: Transduced with a lentiviral construct that contains a B2M-HLA-B fusion protein (Sigma-Aldrich=HLA002).
Knockout cell: Method=ZFN; HGNC; HGNC:914; B2M.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:914; B2M.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:4932; HLA-B (Note=Allele B*15:10).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_C3CE (Jurkat B2M KO)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) Sigma-Aldrich; HLA002
Cell line databases/resources cancercelllines; CVCL_C3CX
Encyclopedic resources Wikidata; Q114311799
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number7