Cellosaurus cell line LNCaP-PDR1 (CVCL

Cellosaurus LNCaP-PDR1 (CVCL_C0RR)

Cross-references
Cell line name	LNCaP-PDR1
Synonyms	LNCaP PDR1; LN-PDR1
Accession	CVCL_C0RR
Resource Identification Initiative	To cite this cell line use: LNCaP-PDR1 (RRID:CVCL_C0RR)
Comments	Population: Caucasian. Selected for resistance to: ChEBI; CHEBI:85993; Palbociclib (Ibrance). Omics: Deep quantitative phosphoproteome analysis. Omics: Transcriptome analysis by RNAseq. Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations	Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line). Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease	Prostate carcinoma (NCIt: C4863)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0395 (LNCaP)
Sex of cell	Male
Age at sampling	50Y
Category	Cancer cell line
Publications	PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410; PMCID=PMC6125187 de Leeuw R., McNair C., Schiewer M.J., Poudel-Neupane N., Brand L.J., Augello M.A., Li Z., Cheng L.C., Yoshida A., Courtney S.M., Hazard E.S., Hardiman G., Hussain M.H., Diehl J.A., Drake J.M., Kelly W.K., Knudsen K.E. MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer. Clin. Cancer Res. 24:4201-4214(2018)
Cell line databases/resources	cancercelllines; CVCL_C0RR
Encyclopedic resources	Wikidata; Q112930019
Gene expression databases	GEO; GSM2650005 GEO; GSM2650006 GEO; GSM2650007 GEO; GSM2650008 GEO; GSM2650009 GEO; GSM2650010
Proteomic databases	PRIDE; PXD006561
Entry history
Entry creation	23-Jun-2022
Last entry update	05-Oct-2023
Version number	5