ID   LNCaP-PDR1
AC   CVCL_C0RR
SY   LNCaP PDR1; LN-PDR1
DR   cancercelllines; CVCL_C0RR
DR   GEO; GSM2650005
DR   GEO; GSM2650006
DR   GEO; GSM2650007
DR   GEO; GSM2650008
DR   GEO; GSM2650009
DR   GEO; GSM2650010
DR   PRIDE; PXD006561
DR   Wikidata; Q112930019
RX   PubMed=29739788;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:85993; Palbociclib (Ibrance).
CC   Sequence variation: Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
CC   Omics: Deep quantitative phosphoproteome analysis.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0395 ! LNCaP
SX   Male
AG   50Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 05-10-23; Version: 5
//
RX   PubMed=29739788; DOI=10.1158/1078-0432.CCR-18-0410;
RA   de Leeuw R., McNair C., Schiewer M.J., Poudel-Neupane N., Brand L.J.,
RA   Augello M.A., Li Z., Cheng L.C., Yoshida A., Courtney S.M.,
RA   Hazard E.S., Hardiman G., Hussain M.H., Diehl J.A., Drake J.M.,
RA   Kelly W.K., Knudsen K.E.;
RT   "MAPK reliance via acquired CDK4/6 inhibitor resistance in cancer.";
RL   Clin. Cancer Res. 24:4201-4214(2018).
//