Cellosaurus 293EL-APP* (CVCL_C0I9)
| Cell line name | 293EL-APP* |
|---|---|
| Accession | CVCL_C0I9 |
| Resource Identification Initiative | To cite this cell line use: 293EL-APP* (RRID:CVCL_C0I9) |
| Comments | Characteristics: Using CRISPR/Cas9 TMEM192 was C-terminally tagged on both alleles with a 3xHA epitope (from parent cell line). Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:620; APP. Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:620; APP (Note=With p.Lys670Asn, p.Met671Leu, p.Thr719Asn = APPSw/T700N). Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3185; EEA1 (Note=With a N-terminal FLAG tag). Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR). Transformant: NCBI_TaxID; 28285; Adenovirus 5. Derived from site: In situ; Fetal kidney; UBERON=UBERON_0002113. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_C0I8 (293EL-APP-/-) |
| Sex of cell | Female |
| Age at sampling | Fetus |
| Category | Transformed cell line |
| Publications | PubMed=36245040; DOI=10.1038/s41467-022-33881-x; PMCID=PMC9573879 |
| Cross-references | |
| Encyclopedic resources | Wikidata; Q112926925 |
| Entry history | |
| Entry creation | 23-Jun-2022 |
| Last entry update | 19-Dec-2024 |
| Version number | 7 |