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Cellosaurus MTX-RAJI (CVCL_B3QL)

[Text version]
Cell line name MTX-RAJI
Accession CVCL_B3QL
Resource Identification Initiative To cite this cell line use: MTX-RAJI (RRID:CVCL_B3QL)
Comments Population: African; Nigerian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Gene fusion; HGNC; HGNC:5477; IGH + HGNC; HGNC:7553; MYC; Name(s)=MYC-IGH (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0511 (Raji)
Sex of cell Male
Age at sampling 11Y
Category Cancer cell line
Publications

PubMed=30993483; DOI=10.1007/s10147-019-01451-9
Hayano A., Takashima Y., Yamanaka R.
Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells.
Int. J. Clin. Oncol. 24:1020-1029(2019)

PubMed=31510952; DOI=10.1186/s12885-019-6129-8; PMCID=PMC6739943
Takashima Y., Yoshimura T., Kano Y., Hayano A., Hondoh H., Ikenaka K., Yamanaka R.
Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells.
BMC Cancer 19:910.1-910.11(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B3QL
Encyclopedic resources Wikidata; Q110433074
Entry history
Entry creation16-Dec-2021
Last entry update19-Dec-2024
Version number7