ID   MTX-RAJI
AC   CVCL_B3QL
DR   cancercelllines; CVCL_B3QL
DR   Wikidata; Q110433074
RX   PubMed=30993483;
RX   PubMed=31510952;
CC   Population: African; Nigerian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr234His (c.700T>C); ClinVar=VCV000376691; Zygosity=Heterozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0511 ! Raji
SX   Male
AG   11Y
CA   Cancer cell line
DT   Created: 16-12-21; Last updated: 05-10-23; Version: 5
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RX   PubMed=30993483; DOI=10.1007/s10147-019-01451-9;
RA   Hayano A., Takashima Y., Yamanaka R.;
RT   "Cell-type-specific sensitivity of bortezomib in the
RT   methotrexate-resistant primary central nervous system lymphoma
RT   cells.";
RL   Int. J. Clin. Oncol. 24:1020-1029(2019).
//
RX   PubMed=31510952; DOI=10.1186/s12885-019-6129-8;
RA   Takashima Y., Yoshimura T., Kano Y., Hayano A., Hondoh H., Ikenaka K.,
RA   Yamanaka R.;
RT   "Differential expression of N-linked oligosaccharides in
RT   methotrexate-resistant primary central nervous system lymphoma
RT   cells.";
RL   BMC Cancer 19:910.1-910.11(2019).
//