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Cellosaurus MDS-L-2007 (CVCL_A8QY)

[Text version]
Cell line name MDS-L-2007
Accession CVCL_A8QY
Resource Identification Initiative To cite this cell line use: MDS-L-2007 (RRID:CVCL_A8QY)
Comments Population: Japanese.
Characteristics: IL3 dependent.
Omics: Deep exome analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; HGNC:1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (PubMed=29955132).
  • Mutation; HGNC; HGNC:4768; H3C3; Simple; p.Lys28Met (c.83A>T); Zygosity=Heterozygous (PubMed=29955132).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=29955132).
Disease Myelodysplastic syndrome (NCIt: C3247)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_A8QV (MDS-L)
Sex of cell Male
Age at sampling 52Y
Category Cancer cell line
STR profile Source(s): PubMed=29955132

Markers:
AmelogeninX,Y
CSF1PO12
D3S135815
D5S81813
D7S82011
D8S117911,13
D13S3178
D16S5399,10
D18S5112,17
D21S1130,32.2
FGA23
Penta D9
Penta E16,18
TH016
TPOX8,11
vWA15,17

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Publications

PubMed=29955132; DOI=10.1038/s41375-018-0189-7
Kida J.-i., Tsujioka T., Suemori S.-i., Okamoto S., Sakakibara K., Takahata T., Yamauchi T., Kitanaka A., Tohyama Y., Tohyama K.
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS.
Leukemia 32:1846-1850(2018)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A8QY
Encyclopedic resources Wikidata; Q108820887
Entry history
Entry creation23-Sep-2021
Last entry update19-Dec-2024
Version number6