ID   MDS-L-2007
AC   CVCL_A8QY
DR   cancercelllines; CVCL_A8QY
DR   Wikidata; Q108820887
RX   PubMed=29955132;
CC   Population: Japanese.
CC   Characteristics: IL3 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (PubMed=29955132).
CC   Sequence variation: Mutation; HGNC; HGNC:4768; H3C3; Simple; p.Lys28Met (c.83A>T); Zygosity=Heterozygous (PubMed=29955132).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=29955132).
CC   Omics: Deep exome analysis.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): PubMed=29955132
ST   Amelogenin: X,Y
ST   CSF1PO: 12
ST   D13S317: 8
ST   D16S539: 9,10
ST   D18S51: 12,17
ST   D21S11: 30,32.2
ST   D3S1358: 15
ST   D5S818: 13
ST   D7S820: 11
ST   D8S1179: 11,13
ST   FGA: 23
ST   Penta D: 9
ST   Penta E: 16,18
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 15,17
DI   NCIt; C3247; Myelodysplastic syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_A8QV ! MDS-L
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 23-09-21; Last updated: 19-12-24; Version: 6
//
RX   PubMed=29955132; DOI=10.1038/s41375-018-0189-7;
RA   Kida J.-i., Tsujioka T., Suemori S.-i., Okamoto S., Sakakibara K.,
RA   Takahata T., Yamauchi T., Kitanaka A., Tohyama Y., Tohyama K.;
RT   "An MDS-derived cell line and a series of its sublines serve as an in
RT   vitro model for the leukemic evolution of MDS.";
RL   Leukemia 32:1846-1850(2018).
//