Cellosaurus cell line MDS-L (CVCL

Cellosaurus MDS-L (CVCL_A8QV)

[Text version]

Cell line name

MDS-L

Synonyms

MDSL

Accession

CVCL_A8QV

Resource Identification Initiative

To cite this cell line use: MDS-L (RRID:CVCL_A8QV)

Comments

Population: Japanese.
Characteristics: IL3 dependent.
Omics: Deep exome analysis.
Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; HGNC:1833; CEBPA; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000851673; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; HGNC:4768; H3C3; Simple; p.Lys28Met (c.83A>T); Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000219097; Zygosity=Heterozygous (PubMed=29955132).
Mutation; HGNC; HGNC:11998; TP53; Simple; c.672+1G>A; ClinVar=VCV000216078; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=29955132).

Disease

Myelodysplastic syndrome (NCIt: C3247)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_A647 (MDS92)
Children:

CVCL_A8QY (MDS-L-2007)	CVCL_A8QW (MDS-L/GFP-N)	CVCL_A8QX (MDS-L/GR-GFP-N)
CVCL_A8QZ (MDS-LGF)

Sex of cell

Male

Age at sampling

52Y

Category

Cancer cell line

STR profile

Source(s): PubMed=29955132

Markers:

Amelogenin	X,Y
CSF1PO	12
D3S1358	15
D5S818	13
D7S820	11
D8S1179	11,13
D13S317	8
D16S539	9,10
D18S51	12,17
D21S11	30,32.2
FGA	23
Penta D	9
Penta E	16,18
TH01	6
TPOX	8,11
vWA	15,17

Web pages

https://www.researchgate.net/post/Where_can_I_get_MDS92_and_MDS-L_cell_lines

Publications

PubMed=11108571; DOI=10.1080/13684730050515787
Nakamura S., Ohnishi K., Yoshida H., Shinjo K., Takeshita A., Tohyama K., Ohno R., Koide Y.
Retrovirus-mediated gene transfer of granulocyte colony-stimulating factor receptor (G-CSFR) cDNA into MDS cells and induction of their differentiation by G-CSF.
Cytokines Cell. Mol. Ther. 6:61-70(2000)

PubMed=20130600; DOI=10.1038/leu.2009.296
Matsuoka A., Tochigi A., Kishimoto M., Nakahara T., Kondo T., Tsujioka T., Tasaka T., Tohyama Y., Tohyama K.
Lenalidomide induces cell death in an MDS-derived cell line with deletion of chromosome 5q by inhibition of cytokinesis.
Leukemia 24:748-755(2010)

PubMed=29955132; DOI=10.1038/s41375-018-0189-7
Kida J.-i., Tsujioka T., Suemori S.-i., Okamoto S., Sakakibara K., Takahata T., Yamauchi T., Kitanaka A., Tohyama Y., Tohyama K.
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS.
Leukemia 32:1846-1850(2018)

Cross-references

Cell line databases/resources

cancercelllines; CVCL_A8QV

Anatomy/cell type resources

BTO; BTO_0006229

Encyclopedic resources

Wikidata; Q108820885

Entry history

Entry creation

23-Sep-2021

Last entry update

19-Dec-2024

Version number