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Cellosaurus SMS-CTR (CVCL_A770)

[Text version]
Cell line name SMS-CTR
Synonyms SMS_CTR; SMSCTR
Accession CVCL_A770
Resource Identification Initiative To cite this cell line use: SMS-CTR (RRID:CVCL_A770)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
From: Reynolds, Charles Patrick; Children's Hospital of Los Angeles; Los Angeles; USA.
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations
  • Mutation; HGNC; 5173; HRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000012601; Zygosity=Homozygous (PubMed=22142829; DepMap=ACH-001196).
Disease Embryonal rhabdomyosarcoma (NCIt: C8971)
Embryonal rhabdomyosarcoma (ORDO: Orphanet_99757)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=21948088

Markers:
AmelogeninX,Y
CSF1PO12
D2S133824
D3S135817
D5S81812
D7S8208,11
D8S117910,12
D13S31711
D16S53910,11
D18S5113
D19S43314
D21S1129,31.2
FGA21,22
TH016
TPOX8,12
vWA18,19

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=2302710
Ozkaynak M.F., Nolta J., Parkman R.
In vitro purging of human rhabdomyosarcoma cells using 4-hydroperoxycyclophosphamide.
Cancer Res. 50:1455-1458(1990)

CLPUB00569
Dickman P.S., Tsokos M.G., Triche T.J.
Biology of rhabdomyosarcoma: cell culture, xenografts, and animal models.
(In book chapter) Rhabdomyosarcoma and related tumors in children and adolescents; Maurer H.M., Ruymann F.B., Pochedly C.E. (eds.); pp.49-88; CRC Press; Boca Raton; USA (1991)

PubMed=8275086; DOI=10.1038/ng1193-230
Galili N., Davis R.J., Fredericks W.J., Mukhopadhyay S., Rauscher F.J. 3rd, Emanuel B.S., Rovera G., Barr F.G.
Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma.
Nat. Genet. 5:230-235(1993)

PubMed=21948088; DOI=10.1158/1078-0432.CCR-11-1004; PMCID=PMC3241994
Belyea B.C., Naini S., Bentley R.C., Linardic C.M.
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.
Clin. Cancer Res. 17:7324-7336(2011)

PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056; PMCID=PMC3271129
Shukla N., Ameur N., Yilmaz I., Nafa K., Lau C.-Y., Marchetti A., Borsu L., Barr F.G., Ladanyi M.
Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways.
Clin. Cancer Res. 18:748-757(2012)

PubMed=23882450; DOI=10.3389/fonc.2013.00183; PMCID=PMC3713458
Hinson A.R.P., Jones R., Crose L.E.S., Belyea B.C., Barr F.G., Linardic C.M.
Human rhabdomyosarcoma cell lines for rhabdomyosarcoma research: utility and pitfalls.
Front. Oncol. 3:183.1-183.12(2013)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A770
Cell_Model_Passport; SIDM01337
DepMap; ACH-001196
Encyclopedic resources Wikidata; Q54954985
Polymorphism and mutation databases Cosmic; 802048
Cosmic; 1097752
Cosmic; 1718105
Cosmic; 2355930
Entry history
Entry creation06-Jun-2012
Last entry update10-Sep-2024
Version number20