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Cellosaurus MDA-MB-435S/1 (CVCL_A6LJ)

[Text version]
Cell line name MDA-MB-435S/1
Synonyms MDA MB 435 S1; MDA MB 435, subline S1
Accession CVCL_A6LJ
Resource Identification Initiative To cite this cell line use: MDA-MB-435S/1 (RRID:CVCL_A6LJ)
Comments Problematic cell line: Contaminated. Grand-parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0622 (MDA-MB-435S)
CVCL_6684 (MDA-MB-435HGF)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line

PubMed=2007622; DOI=10.1083/jcb.113.1.173
Frixen U.H., Behrens J., Sachs M., Eberle G., Voss B., Warda A., Lochner D., Birchmeier W.
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
J. Cell Biol. 113:173-185(1991)

PubMed=9467938; DOI=10.1038/sj.onc.1201486
Meiners S., Brinkmann V., Naundorf H., Birchmeier W.
Role of morphogenetic factors in metastasis of mammary carcinoma cells.
Oncogene 16:9-20(1998)

Cell line databases/resources cancercelllines; CVCL_A6LJ
Encyclopedic resources Wikidata; Q107116178
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number6