Cellosaurus cell line MDA-MB-435HGF (CVCL

Cellosaurus MDA-MB-435HGF (CVCL_6684)

Cross-references
Cell line name	MDA-MB-435HGF
Synonyms	MDA-MB-435-HGF; MDA-MB-435 HGF; MDAMB-435-HGF; MDA-MB-HGF; HGF1
Accession	CVCL_6684
Resource Identification Initiative	To cite this cell line use: MDA-MB-435HGF (RRID:CVCL_6684)
Comments	Problematic cell line: Contaminated. Ancestral cell line (MDA-MB-435) has been shown to be a M14 derivative. Population: Caucasian. Transfected with: HGNC; 4893; HGF. Transfected with: UniProtKB; P00552; Transposon Tn5 neo. Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations	Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line). Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease	Amelanotic melanoma (NCIt: C3802)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_A6LJ (MDA-MB-435S/1)
Sex of cell	Male
Age at sampling	33Y
Category	Cancer cell line
Publications	PubMed=9467938; DOI=10.1038/sj.onc.1201486 Meiners S., Brinkmann V., Naundorf H., Birchmeier W. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene 16:9-20(1998) PubMed=12354931; DOI=10.1136/mp.55.5.294 Ellison G., Klinowska T., Westwood R.F.R., Docter E., French T., Fox J.C. Further evidence to support the melanocytic origin of MDA-MB-435. Mol. Pathol. 55:294-299(2002)
Cell line databases/resources	cancercelllines; CVCL_6684
Anatomy/cell type resources	BTO; BTO:0004164
Encyclopedic resources	Wikidata; Q54904636
Entry history
Entry creation	04-Apr-2012
Last entry update	05-Oct-2023
Version number	22