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Cellosaurus UM-SCC-5PT (CVCL_A5TN)

[Text version]
Cell line name UM-SCC-5PT
Synonyms UM-5PT; 5PT; 5 PT
Accession CVCL_A5TN
Resource Identification Initiative To cite this cell line use: UM-SCC-5PT (RRID:CVCL_A5TN)
Comments Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
Sequence variations
  • Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=16020667).
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_7762 (UM-SCC-5)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
Publications

PubMed=14720192; DOI=10.1111/j.1600-0714.2004.00157.x
Mackenzie I.C.
Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa.
J. Oral Pathol. Med. 33:71-78(2004)

PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081
Bauer J.A., Trask D.K., Kumar B., Los G., Castro J., Lee J.S.-J., Chen J.-Y., Wang S.-M., Bradford C.R., Carey T.E.
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.
Mol. Cancer Ther. 4:1096-1104(2005)

PubMed=17944752; DOI=10.1111/j.1600-0714.2007.00617.x
Harper L.J., Piper K., Common J., Fortune F., Mackenzie I.C.
Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma.
J. Oral Pathol. Med. 36:594-603(2007)

PubMed=20426848; DOI=10.1186/1471-2407-10-166
Harper L.J., Costea D.E., Gammon L., Fazil B., Biddle A., Mackenzie I.C.
Normal and malignant epithelial cells with stem-like properties have an extended G2 cell cycle phase that is associated with apoptotic resistance.
BMC Cancer 10:166.1-166.16(2010)

Cross-references
Encyclopedic resources Wikidata; Q107117256
Entry history
Entry creation20-May-2021
Last entry update29-Jun-2023
Version number4