ID   UM-SCC-5PT
AC   CVCL_A5TN
SY   UM-5PT; 5PT; 5 PT
DR   Wikidata; Q107117256
RX   PubMed=14720192;
RX   PubMed=16020667;
RX   PubMed=17944752;
RX   PubMed=20426848;
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; None_reported; -; Zygosity=- (PubMed=16020667).
CC   Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7762 ! UM-SCC-5
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 29-06-23; Version: 4
//
RX   PubMed=14720192; DOI=10.1111/j.1600-0714.2004.00157.x;
RA   Mackenzie I.C.;
RT   "Growth of malignant oral epithelial stem cells after seeding into
RT   organotypical cultures of normal mucosa.";
RL   J. Oral Pathol. Med. 33:71-78(2004).
//
RX   PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081;
RA   Bauer J.A., Trask D.K., Kumar B., Los G., Castro J., Lee J.S.-J.,
RA   Chen J.-Y., Wang S.-M., Bradford C.R., Carey T.E.;
RT   "Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in
RT   head and neck cancer cells: role of wild-type p53 and Bcl-xL.";
RL   Mol. Cancer Ther. 4:1096-1104(2005).
//
RX   PubMed=17944752; DOI=10.1111/j.1600-0714.2007.00617.x;
RA   Harper L.J., Piper K., Common J., Fortune F., Mackenzie I.C.;
RT   "Stem cell patterns in cell lines derived from head and neck squamous
RT   cell carcinoma.";
RL   J. Oral Pathol. Med. 36:594-603(2007).
//
RX   PubMed=20426848; DOI=10.1186/1471-2407-10-166;
RA   Harper L.J., Costea D.E., Gammon L., Fazil B., Biddle A.,
RA   Mackenzie I.C.;
RT   "Normal and malignant epithelial cells with stem-like properties have
RT   an extended G2 cell cycle phase that is associated with apoptotic
RT   resistance.";
RL   BMC Cancer 10:166.1-166.16(2010).
//