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Cellosaurus UM-SCC-5 (CVCL_7762)

[Text version]
Cell line name UM-SCC-5
Synonyms UMSCC-5; UM-SCC5; UMSCC5; University of Michigan-Squamous Cell Carcinoma-5
Accession CVCL_7762
Resource Identification Initiative To cite this cell line use: UM-SCC-5 (RRID:CVCL_7762)
Comments Part of: MD Anderson Cell Lines Project.
Omics: Protein expression by reverse-phase protein arrays.
Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
Sequence variations
Disease Laryngeal squamous cell carcinoma (NCIt: C4044)
Squamous cell carcinoma of the larynx (ORDO: Orphanet_494550)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A5TN (UM-SCC-5PT)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=19760794

Markers:
AmelogeninX
D3S135817
D5S81813
D7S8209
D8S117911,13
D13S3178,11
D18S5112,16
D21S1131
FGA25
vWA18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=3855324; DOI=10.1288/00005537-198501000-00012
Baker S.R.
An in vivo model for squamous cell carcinoma of the head and neck.
Laryngoscope 95:43-56(1985)

PubMed=1851275; DOI=10.1177/019459989110400304
Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D., Carey T.E.
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
Otolaryngol. Head Neck Surg. 104:303-310(1991)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In book chapter) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York; USA (1994)

PubMed=12884349; DOI=10.1002/hed.10274
Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A., Johnson G., Wolf G.T., Fisher S.G., Carey T.E.
p53 mutation correlates with cisplatin sensitivity in head and neck squamous cell carcinoma lines.
Head Neck 25:654-661(2003)

PubMed=14720192; DOI=10.1111/j.1600-0714.2004.00157.x
Mackenzie I.C.
Growth of malignant oral epithelial stem cells after seeding into organotypical cultures of normal mucosa.
J. Oral Pathol. Med. 33:71-78(2004)

PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081
Bauer J.A., Trask D.K., Kumar B., Los G., Castro J., Lee J.S.-J., Chen J.-Y., Wang S.-M., Bradford C.R., Carey T.E.
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.
Mol. Cancer Ther. 4:1096-1104(2005)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=19760794; DOI=10.1002/hed.21198; PMCID=PMC3292176
Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R., Lyons R.H., Bradford C.R., Carey T.E.
Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.
Head Neck 32:417-426(2010)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7762
Anatomy/cell type resources BTO; BTO_0004023
Encyclopedic resources Wikidata; Q54990881
Polymorphism and mutation databases IARC_TP53; 18874
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21