ID   UM-SCC-5
AC   CVCL_7762
SY   UMSCC-5; UM-SCC5; UMSCC5; University of Michigan-Squamous Cell Carcinoma-5
DR   BTO; BTO:0004023
DR   cancercelllines; CVCL_7762
DR   IARC_TP53; 18874
DR   Wikidata; Q54990881
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1851275;
RX   PubMed=3855324;
RX   PubMed=12884349;
RX   PubMed=14720192;
RX   PubMed=16020667;
RX   PubMed=17312569;
RX   PubMed=19760794;
RX   PubMed=28196595;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Heterozygous (PubMed=12884349).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Derived from site: In situ; Larynx, supraglottis; UBERON=UBERON_0036263.
ST   Source(s): PubMed=19760794
ST   Amelogenin: X
ST   D13S317: 8,11
ST   D18S51: 12,16
ST   D21S11: 31
ST   D3S1358: 17
ST   D5S818: 13
ST   D7S820: 9
ST   D8S1179: 11,13
ST   FGA: 25
ST   vWA: 18
DI   NCIt; C4044; Laryngeal squamous cell carcinoma
DI   ORDO; Orphanet_494550; Squamous cell carcinoma of the larynx
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 20
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1851275; DOI=10.1177/019459989110400304;
RA   Bradford C.R., Zacks S.E., Androphy E.J., Gregoire L., Lancaster W.D.,
RA   Carey T.E.;
RT   "Human papillomavirus DNA sequences in cell lines derived from head
RT   and neck squamous cell carcinomas.";
RL   Otolaryngol. Head Neck Surg. 104:303-310(1991).
//
RX   PubMed=3855324; DOI=10.1288/00005537-198501000-00012;
RA   Baker S.R.;
RT   "An in vivo model for squamous cell carcinoma of the head and neck.";
RL   Laryngoscope 95:43-56(1985).
//
RX   PubMed=12884349; DOI=10.1002/hed.10274;
RA   Bradford C.R., Zhu S.-B., Ogawa H., Ogawa T., Ubell M., Narayan A.,
RA   Johnson G., Wolf G.T., Fisher S.G., Carey T.E.;
RT   "P53 mutation correlates with cisplatin sensitivity in head and neck
RT   squamous cell carcinoma lines.";
RL   Head Neck 25:654-661(2003).
//
RX   PubMed=14720192; DOI=10.1111/j.1600-0714.2004.00157.x;
RA   Mackenzie I.C.;
RT   "Growth of malignant oral epithelial stem cells after seeding into
RT   organotypical cultures of normal mucosa.";
RL   J. Oral Pathol. Med. 33:71-78(2004).
//
RX   PubMed=16020667; DOI=10.1158/1535-7163.MCT-05-0081;
RA   Bauer J.A., Trask D.K., Kumar B., Los G., Castro J., Lee J.S.-J.,
RA   Chen J.-Y., Wang S.-M., Bradford C.R., Carey T.E.;
RT   "Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in
RT   head and neck cancer cells: role of wild-type p53 and Bcl-xL.";
RL   Mol. Cancer Ther. 4:1096-1104(2005).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=19760794; DOI=10.1002/hed.21198;
RA   Brenner J.C., Graham M.P., Kumar B., Saunders L.M., Kupfer R.,
RA   Lyons R.H., Bradford C.R., Carey T.E.;
RT   "Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell
RT   lines.";
RL   Head Neck 32:417-426(2010).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//