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Cellosaurus SCMC-L2 (CVCL_7128)

[Text version]
Cell line name SCMC-L2
Synonyms SCMC-L-2; SCMCL2; L2; Saitama Children's Medical Center-Leukemia 2
Accession CVCL_7128
Resource Identification Initiative To cite this cell line use: SCMC-L2 (RRID:CVCL_7128)
Comments Population: Japanese.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072).
  • Mutation; HGNC; HGNC:12766; NSD2; Simple; c.2675+2T>C; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=35124168).
Disease Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C68659)
B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_585909)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 10Y
Category Cancer cell line
Publications

CLPUB00110
Hayashi Y., Hanada R., Moriwaki K., Yamamoto K., Imaizumi S., Hirata A., Nishida T.
Establishment and characterization of cell lines derived from malignant tumors in children.
Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991)

CLPUB00111
Hayashi Y., Kawamura M., Kobayashi S., Moriwaki K., Kobayashi M., Bessho F., Hanada R., Yamamoto K., Mori T., Nakazawa S., Yaginuma Y., Honma Y., Hozumi M.
Establishment and characterization of cell lines derived from childhood leukemias.
Int. J. Hematol. 57 Suppl. 1:124-124(1993)

PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x
Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K., Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.
Effects of herbimycin A and its derivatives on growth and differentiation of Ph1-positive acute lymphoid leukemia cell lines.
Leuk. Res. 18:221-228(1994)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Encyclopedic resources Wikidata; Q54952455
Polymorphism and mutation databases Cosmic; 1037739
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number15