ID   SCMC-L2
AC   CVCL_7128
SY   SCMC-L-2; SCMCL2; L2; Saitama Children's Medical Center-Leukemia 2
DR   Cosmic; 1037739
DR   Wikidata; Q54952455
RX   CelloPub=CLPUB00110;
RX   CelloPub=CLPUB00111;
RX   PubMed=8139288;
RX   PubMed=10071072;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=10071072).
CC   Sequence variation: Mutation; HGNC; HGNC:12766; NSD2; Simple; c.2675+2T>C; Zygosity=Heterozygous; Note=Splice donor mutation (PubMed=35124168).
DI   NCIt; C68659; Childhood B acute lymphoblastic leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1
DI   ORDO; Orphanet_585909; B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   10Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 15
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RX   CelloPub=CLPUB00110;
RA   Hayashi Y., Hanada R., Moriwaki K., Yamamoto K., Imaizumi S.,
RA   Hirata A., Nishida T.;
RT   "Establishment and characterization of cell lines derived from
RT   malignant tumors in children.";
RL   Saitama Shoni Iryo Senta Igaku-shi 8:16-23(1991).
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RX   CelloPub=CLPUB00111;
RA   Hayashi Y., Kawamura M., Kobayashi S., Moriwaki K., Kobayashi M.,
RA   Bessho F., Hanada R., Yamamoto K., Mori T., Nakazawa S., Yaginuma Y.,
RA   Honma Y., Hozumi M.;
RT   "Establishment and characterization of cell lines derived from
RT   childhood leukemias.";
RL   Int. J. Hematol. 57 Suppl. 1:124-124(1993).
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RX   PubMed=8139288; DOI=10.1016/0145-2126(94)90118-x;
RA   Sato S., Honma Y., Hozumi M., Hayashi Y., Matsuo Y., Shibata K.,
RA   Omura S., Hino K.-i., Tomoyasu S., Tsuruoka N.;
RT   "Effects of herbimycin A and its derivatives on growth and
RT   differentiation of Ph1-positive acute lymphoid leukemia cell lines.";
RL   Leuk. Res. 18:221-228(1994).
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RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
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RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
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RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//