| Abstract |
Morphologic, cytogenetic, immunologic, and molecular studies were
performed on 11 solid tumor cell lines and four leukemia cell lines
established from 15 patients in children. Four neuroblastoma cell lines
(SCMC-N2-N5) had N-myc amplification, three of them had DMs, and remaining
one had HSRs. One of the two rhabdomyosarcoma cell lines (SCMC-RM1, RM2)
had N-myc amplification and t(9:13). Two Wilms tumor cell lines (SCMC-W1,
W2) were derived from rhabdoid type, and two Ewing sarcoma cell lines
(SCMC-ES1, ES2) had t(11:22). One cell line derived from malignant
mesenchymoma had the capacity of differentiation into muscle or neuron,
suggesting to be of undifferentiated stem cell origin. SCMC-L1 derived
from infant ALL expressed early precursor B lineage, and SCMC-L2 with Ph1ALL
expressed both lymphoid and myeloid antigens, having mixed lineage
characteristic. Two cell lines from Burkitt's lymphoma (SCMC-L3, L4) had
t(8:22) and t(8:14), respectively. These cell lines will be valuable
resources in ascertaining the biological characteristics and
clinicopathology of the childhood malignant tumors.
|
|---|
