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Cellosaurus SCC-61 (CVCL_7118)

[Text version]
Cell line name SCC-61
Synonyms SCC 61; SCC61
Accession CVCL_7118
Resource Identification Initiative To cite this cell line use: SCC-61 (RRID:CVCL_7118)
Comments Part of: MD Anderson Cell Lines Project.
Characteristics: Good model for studying radiation resistance in squamous cell carcinoma (Millipore=SCC280).
Characteristics: Sensitive to radiation (PubMed=2004949).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Oral cavity, tongue, anterior part; UBERON=UBERON_0010032.
Sequence variations
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=17848307).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Squamous cell carcinoma of the oral tongue (ORDO: Orphanet_457252)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_7086 (Nu61)CVCL_V282 (SCC-61B)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): Millipore; PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135815
D5S81812,13
D7S8208,12
D8S117912,14
D13S31710,12
D16S5399,11
D18S5112,14
D21S1128,30
FGA22,25
Penta D10,12
Penta E7,11
TH017,9
TPOX8
vWA16,17

Run an STR similarity search on this cell line
Web pages https://strap.nci.nih.gov/celline_detail.php?sample_id=79
https://tcpaportal.org/mclp/
Publications

PubMed=6722007; DOI=10.1038/bjc.1984.94
Weichselbaum R.R., Dahlberg W.K., Little J.B., Ervin T.J., Miller D., Hellman S., Rheinwald J.G.
Cellular X-ray repair parameters of early passage squamous cell carcinoma lines derived from patients with known responses to radiotherapy.
Br. J. Cancer 49:595-601(1984)

PubMed=3458227; DOI=10.1073/pnas.83.8.2684
Weichselbaum R.R., Dahlberg W.K., Beckett M.A., Karrison T., Miller D., Clark J., Ervin T.J.
Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.
Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986)

PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3
Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B., Weichselbaum R.R.
Faster repair of DNA double-strand breaks in radioresistant human tumor cells.
Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988)

PubMed=2573646; DOI=10.1080/09553008914551731
Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.
Radiobiological characterization of 53 human tumor cell lines.
Int. J. Radiat. Biol. 56:553-560(1989)

PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8
Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.
The interaction between recombinant human tumor necrosis factor and radiation in 13 human tumor cell lines.
Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990)

PubMed=2394610; DOI=10.1016/0360-3016(90)90539-V
Weichselbaum R.R., Beckett M.A., Vijayakumar S., Simon M.A., Awan A.M., Nachman J., Panje W.R., Goldman M.E., Tybor A.G., Moran W.J., Vokes E.E., Ahmed-Swan S., Farhangi E.
Radiobiological characterization of head and neck and sarcoma cells derived from patients prior to radiotherapy.
Int. J. Radiat. Oncol. Biol. Phys. 19:313-319(1990)

PubMed=2004949; DOI=10.1016/0360-3016(91)90016-W
Quiet C.A., Weichselbaum R.R., Grdina D.J.
Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 20:733-738(1991)

PubMed=1574572; DOI=10.2307/3578273
Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
Radiat. Res. 130:166-170(1992)

PubMed=8339273
Brachman D.G., Beckett M.A., Graves D., Haraf D., Vokes E.E., Weichselbaum R.R.
p53 mutation does not correlate with radiosensitivity in 24 head and neck cancer cell lines.
Cancer Res. 53:3667-3669(1993)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=7938462; DOI=10.2307/3578897
Smeets M.F.M.A., Mooren E.H.M., Abdel-Wahab A.H.A., Bartelink H., Begg A.C.
Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks.
Radiat. Res. 140:153-160(1994)

DOI=10.1007/978-1-4615-2023-8_7
Weichselbaum R.R., Beckett M.A., Vokes E.E., Brachman D.G., Haraf D., Hallahan D.E., Kufe D.W.
Cellular and molecular mechanisms of radioresistance.
(In) Head and neck cancer. Cancer treatment and research, Vol. 74; Hong W.K., Weber R.S. (eds.); pp.131-140; Springer; Boston (1995)

PubMed=17312569; DOI=10.1002/hed.20478
Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L., Koch W.M., Ferris R.L., Lai S.Y.
Head and neck squamous cell carcinoma cell lines: established models and rationale for selection.
Head Neck 29:163-188(2007)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y., Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections (Providers) Millipore; SCC280
Encyclopedic resources Wikidata; Q54952349
Polymorphism and mutation databases Cosmic; 1122673
Cosmic; 1530756
Entry history
Entry creation04-Apr-2012
Last entry update30-Jan-2024
Version number23