ID   SCC-61
AC   CVCL_7118
SY   SCC 61; SCC61
DR   Cosmic; 1122673
DR   Cosmic; 1530756
DR   Millipore; SCC280
DR   Wikidata; Q54952349
RX   DOI=10.1007/978-1-4615-2023-8_7;
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RX   PubMed=1574572;
RX   PubMed=2004949;
RX   PubMed=2380097;
RX   PubMed=2394610;
RX   PubMed=2573646;
RX   PubMed=3182330;
RX   PubMed=3458227;
RX   PubMed=6722007;
RX   PubMed=7938462;
RX   PubMed=8339273;
RX   PubMed=17312569;
RX   PubMed=17848307;
RX   PubMed=21868764;
RX   PubMed=28196595;
RX   PubMed=29156801;
WW   https://strap.nci.nih.gov/celline_detail.php?sample_id=79
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Characteristics: Good model for studying radiation resistance in squamous cell carcinoma (Millipore=SCC280).
CC   Characteristics: Sensitive to radiation (PubMed=2004949).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu542Lys (c.1624G>A); ClinVar=VCV000031944; Zygosity=Unspecified (PubMed=17848307).
CC   Omics: Deep exome analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Oral cavity, tongue, anterior part; UBERON=UBERON_0010032.
ST   Source(s): Millipore; PubMed=21868764
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 9,11
ST   D18S51: 12,14
ST   D21S11: 28,30
ST   D3S1358: 15
ST   D5S818: 12,13
ST   D7S820: 8,12
ST   D8S1179: 12,14
ST   FGA: 22,25
ST   Penta D: 10,12
ST   Penta E: 7,11
ST   TH01: 7,9
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 30-01-24; Version: 23
//
RX   DOI=10.1007/978-1-4615-2023-8_7;
RA   Weichselbaum R.R., Beckett M.A., Vokes E.E., Brachman D.G.,
RA   Haraf D., Hallahan D.E., Kufe D.W.;
RT   "Cellular and molecular mechanisms of radioresistance.";
RL   (In) Head and neck cancer. Cancer treatment and research, Vol. 74; Hong W.K., Weber R.S. (eds.); pp.131-140; Springer; Boston (1995).
//
RX   DOI=10.1016/B978-0-12-333530-2.50007-1;
RA   Carey T.E.;
RT   "Head and neck tumor cell lines.";
RL   (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994).
//
RX   PubMed=1574572; DOI=10.2307/3578273;
RA   Dunphy E.J., Beckett M.A., Thompson L.H., Weichselbaum R.R.;
RT   "Expression of the polymorphic human DNA repair gene XRCC1 does not
RT   correlate with radiosensitivity in the cells of human head and neck
RT   tumor cell lines.";
RL   Radiat. Res. 130:166-170(1992).
//
RX   PubMed=2004949; DOI=10.1016/0360-3016(91)90016-W;
RA   Quiet C.A., Weichselbaum R.R., Grdina D.J.;
RT   "Variation in radiation sensitivity during the cell cycle of two human
RT   squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 20:733-738(1991).
//
RX   PubMed=2380097; DOI=10.1016/0360-3016(90)90136-8;
RA   Hallahan D.E., Beckett M.A., Kufe D.W., Weichselbaum R.R.;
RT   "The interaction between recombinant human tumor necrosis factor and
RT   radiation in 13 human tumor cell lines.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 19:69-74(1990).
//
RX   PubMed=2394610; DOI=10.1016/0360-3016(90)90539-V;
RA   Weichselbaum R.R., Beckett M.A., Vijayakumar S., Simon M.A.,
RA   Awan A.M., Nachman J., Panje W.R., Goldman M.E., Tybor A.G.,
RA   Moran W.J., Vokes E.E., Ahmed-Swan S., Farhangi E.;
RT   "Radiobiological characterization of head and neck and sarcoma cells
RT   derived from patients prior to radiotherapy.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 19:313-319(1990).
//
RX   PubMed=2573646; DOI=10.1080/09553008914551731;
RA   Weichselbaum R.R., Rotmensch J., Ahmed-Swan S., Beckett M.A.;
RT   "Radiobiological characterization of 53 human tumor cell lines.";
RL   Int. J. Radiat. Biol. 56:553-560(1989).
//
RX   PubMed=3182330; DOI=10.1016/0360-3016(88)90125-3;
RA   Schwartz J.L., Rotmensch J., Giovanazzi S., Cohen M.B.,
RA   Weichselbaum R.R.;
RT   "Faster repair of DNA double-strand breaks in radioresistant human
RT   tumor cells.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 15:907-912(1988).
//
RX   PubMed=3458227; DOI=10.1073/pnas.83.8.2684;
RA   Weichselbaum R.R., Dahlberg W.K., Beckett M.A., Karrison T., Miller D.,
RA   Clark J., Ervin T.J.;
RT   "Radiation-resistant and repair-proficient human tumor cells may be
RT   associated with radiotherapy failure in head- and neck-cancer
RT   patients.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:2684-2688(1986).
//
RX   PubMed=6722007; DOI=10.1038/bjc.1984.94;
RA   Weichselbaum R.R., Dahlberg W.K., Little J.B., Ervin T.J., Miller D.,
RA   Hellman S., Rheinwald J.G.;
RT   "Cellular X-ray repair parameters of early passage squamous cell
RT   carcinoma lines derived from patients with known responses to
RT   radiotherapy.";
RL   Br. J. Cancer 49:595-601(1984).
//
RX   PubMed=7938462; DOI=10.2307/3578897;
RA   Smeets M.F.M.A., Mooren E.H.M., Abdel-Wahab A.H.A., Bartelink H.,
RA   Begg A.C.;
RT   "Differential repair of radiation-induced DNA damage in cells of human
RT   squamous cell carcinoma and the effect of caffeine and cysteamine on
RT   induction and repair of DNA double-strand breaks.";
RL   Radiat. Res. 140:153-160(1994).
//
RX   PubMed=8339273;
RA   Brachman D.G., Beckett M.A., Graves D., Haraf D., Vokes E.E.,
RA   Weichselbaum R.R.;
RT   "p53 mutation does not correlate with radiosensitivity in 24 head and
RT   neck cancer cell lines.";
RL   Cancer Res. 53:3667-3669(1993).
//
RX   PubMed=17312569; DOI=10.1002/hed.20478;
RA   Lin C.J., Grandis J.R., Carey T.E., Gollin S.M., Whiteside T.L.,
RA   Koch W.M., Ferris R.L., Lai S.Y.;
RT   "Head and neck squamous cell carcinoma cell lines: established models
RT   and rationale for selection.";
RL   Head Neck 29:163-188(2007).
//
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough W.G., Whigham A., Brown B., Roach M., Slebos R.J.C.;
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
//
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//