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Cellosaurus HGL5 (CVCL_6644)

[Text version]
Cell line name HGL5
Synonyms HGL-5
Accession CVCL_6644
Resource Identification Initiative To cite this cell line use: HGL5 (RRID:CVCL_6644)
Comments Doubling time: 96 hours (Note=At 75th passage) (PubMed=8126145).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from an IVF patient undergoing oocyte retrieval procedure (PubMed=8126145).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3DF (HGL5-MXIV)CVCL_E3DG (HGL5-YAP(S127A))
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=8126145; DOI=10.1210/jcem.78.3.8126145
Rainey W.E., Sawetawan C., Shay J.W., Michael M.D., Mathis J.M., Kutteh W.H., Byrd W., Carr B.R.
Transformation of human granulosa cells with the E6 and E7 regions of human papillomavirus.
J. Clin. Endocrinol. Metab. 78:705-710(1994)

PubMed=15541573; DOI=10.1016/j.mce.2004.04.018
Havelock J.C., Rainey W.E., Carr B.R.
Ovarian granulosa cell lines.
Mol. Cell. Endocrinol. 228:67-78(2004)

PubMed=22949596
Bouraki G., Metallinou C., Simopoulou M., Charalabopoulos K., Asimakopoulos B.
Comparison of nine media in the culture of human ovarian granulosa lutein cells.
In Vivo 26:823-825(2012)

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K., Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J., Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L., Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Cross-references
Cell line collections (Providers) ABM; T0650
Encyclopedic resources Wikidata; Q54887287
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number14