ID   HGL5
AC   CVCL_6644
SY   HGL-5
DR   Wikidata; Q54887287
RX   PubMed=8126145;
RX   PubMed=15541573;
RX   PubMed=22949596;
RX   PubMed=34888112;
CC   Doubling time: 96 hours (Note=At 75th passage) (PubMed=8126145).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Donor information: Established from an IVF patient undergoing oocyte retrieval procedure (PubMed=8126145).
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
CC   Cell type: Granulosa cell; CL=CL_0000501.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 13
//
RX   PubMed=8126145; DOI=10.1210/jcem.78.3.8126145;
RA   Rainey W.E., Sawetawan C., Shay J.W., Michael M.D., Mathis J.M.,
RA   Kutteh W.H., Byrd W., Carr B.R.;
RT   "Transformation of human granulosa cells with the E6 and E7 regions of
RT   human papillomavirus.";
RL   J. Clin. Endocrinol. Metab. 78:705-710(1994).
//
RX   PubMed=15541573; DOI=10.1016/j.mce.2004.04.018;
RA   Havelock J.C., Rainey W.E., Carr B.R.;
RT   "Ovarian granulosa cell lines.";
RL   Mol. Cell. Endocrinol. 228:67-78(2004).
//
RX   PubMed=22949596;
RA   Bouraki G., Metallinou C., Simopoulou M., Charalabopoulos K.,
RA   Asimakopoulos B.;
RT   "Comparison of nine media in the culture of human ovarian granulosa
RT   lutein cells.";
RL   In Vivo 26:823-825(2012).
//
RX   PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108;
RA   Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K.,
RA   Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J.,
RA   Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L.,
RA   Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.;
RT   "Reprogramming of ovarian granulosa cells by YAP1 leads to development
RT   of high-grade cancer with mesenchymal lineage and serous features.";
RL   Sci. Bull. 65:1281-1296(2020).
//