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Cellosaurus HGL5-MXIV (CVCL_E3DF)

[Text version]
Cell line name HGL5-MXIV
Accession CVCL_E3DF
Resource Identification Initiative To cite this cell line use: HGL5-MXIV (RRID:CVCL_E3DF)
Comments Characteristics: Control cell line for HGL5-YAP(S127A) (Cellosaurus=CVCL_E3DG). Transduced with an empty vector (PubMed=34888112).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Donor information: Established from an IVF patient undergoing oocyte retrieval procedure (from parent cell line).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6644 (HGL5)
Sex of cell Female
Age at sampling Adult
Category Transformed cell line
Publications

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K., Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J., Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L., Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2