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Cellosaurus P116 (CVCL_6429)

[Text version]
Cell line name P116
Accession CVCL_6429
Resource Identification Initiative To cite this cell line use: P116 (RRID:CVCL_6429)
Comments Population: Caucasian.
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_6430 (P116.cl39)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2676

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135815,17
D5S8189
D7S8208,11.3
D8S117913,14
D13S3178,12
D16S53911
D18S5113,21
D19S43314,15.2
D21S1131.2,34.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=9488454; DOI=10.1128/mcb.18.3.1388; PMCID=PMC108852
Williams B.L., Schreiber K.L., Zhang W.-G., Wange R.L., Samelson L.E., Leibson P.J., Abraham R.T.
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
Mol. Cell. Biol. 18:1388-1399(1998)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2676
Cell line databases/resources CLO; CLO_0008292
cancercelllines; CVCL_6429
TOKU-E; 2820
Biological sample resources BioSample; SAMN03471760
Chemistry resources GDSC; 1330986
PharmacoDB; P116_1229_2019
Encyclopedic resources Wikidata; Q54937222
Gene expression databases GEO; GSM827152
Polymorphism and mutation databases Progenetix; CVCL_6429
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number28