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Cellosaurus P116.cl39 (CVCL_6430)

[Text version]
Cell line name P116.cl39
Synonyms P116.c39
Accession CVCL_6430
Resource Identification Initiative To cite this cell line use: P116.cl39 (RRID:CVCL_6430)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 12858; ZAP70 (Note=With a N-terminal Myc tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6429 (P116)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2677

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135815,17
D5S8189
D7S8208,11.3
D8S117912,13,14
D13S3178,12
D16S53911
D18S5113,20
D19S43314,15.2
D21S1132.2,33.2,34.2
FGA20,21
Penta D11,12
Penta E10,12
TH016,9.3
TPOX8,10
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=9488454; DOI=10.1128/mcb.18.3.1388; PMCID=PMC108852
Williams B.L., Schreiber K.L., Zhang W.-G., Wange R.L., Samelson L.E., Leibson P.J., Abraham R.T.
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
Mol. Cell. Biol. 18:1388-1399(1998)

Cross-references
Cell line collections (Providers) ATCC; CRL-2677
Cell line databases/resources CLO; CLO_0008293
cancercelllines; CVCL_6430
LINCS_LDP; LCL-1032
Biological sample resources BioSample; SAMN03471762
Encyclopedic resources Wikidata; Q54937223
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number28