| Cell line name |
P116.cl39 |
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| Synonyms |
P116.c39 |
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| Accession |
CVCL_6430 |
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| Resource Identification Initiative |
To cite this cell line use: P116.cl39 (RRID:CVCL_6430) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 12858; ZAP70 (Note=With a N-terminal Myc tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_6429 (P116) |
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| Sex of cell |
Male |
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| Age at sampling |
14Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ATCC=CRL-2677
Markers:| Amelogenin | X |
| CSF1PO | 11,12 |
| D2S1338 | 18,23 |
| D3S1358 | 15,17 |
| D5S818 | 9 |
| D7S820 | 8,11.3 |
| D8S1179 | 12,13,14 |
| D13S317 | 8,12 |
| D16S539 | 11 |
| D18S51 | 13,20 |
| D19S433 | 14,15.2 |
| D21S11 | 32.2,33.2,34.2 |
| FGA | 20,21 |
| Penta D | 11,12 |
| Penta E | 10,12 |
| TH01 | 6,9.3 |
| TPOX | 8,10 |
| vWA | 19 |
Run an STR similarity search on this cell line |
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| Publications | PubMed=9488454; DOI=10.1128/mcb.18.3.1388; PMCID=PMC108852
Williams B.L., Schreiber K.L., Zhang W.-G., Wange R.L., Samelson L.E., Leibson P.J., Abraham R.T.
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
Mol. Cell. Biol. 18:1388-1399(1998) |
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| Cross-references |
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| Cell line collections (Providers) |
ATCC; CRL-2677
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| Cell line databases/resources |
CLO; CLO_0008293
cancercelllines; CVCL_6430
LINCS_LDP; LCL-1032
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| Biological sample resources |
BioSample; SAMN03471762
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| Encyclopedic resources |
Wikidata; Q54937223
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 28 |
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