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Cellosaurus J.gamma1 (CVCL_6410)

[Text version]
Cell line name J.gamma1
Synonyms Jgamma1; Jurkat Gamma1
Accession CVCL_6410
Resource Identification Initiative To cite this cell line use: J.gamma1 (RRID:CVCL_6410)
Comments Population: Caucasian.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Omics: Deep phosphoproteome analysis.
Omics: SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Children:
CVCL_6411 (J.gamma1.WT)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-2678

Markers:
AmelogeninX
CSF1PO11,12
D2S133818,23
D3S135815,17
D5S8189
D7S8208,12
D8S117913,14
D13S3178,12
D16S53911
D18S5113,20
D19S43314,15.2
D21S1131.2,35.2
FGA20,21
Penta D10,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=11094067; DOI=10.1128/mcb.20.24.9149-9161.2000; PMCID=PMC102173
Irvin B.J., Williams B.L., Nilson A.E., Maynor H.O., Abraham R.T.
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol. Cell. Biol. 20:9149-9161(2000)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=26546556; DOI=10.1016/j.jprot.2015.10.029
Nguyen T.D., Carrascal M., Vidal-Cortes O., Gallardo O., Casas V., Gay M., Phan V.C., Abian J.
The phosphoproteome of human Jurkat T cell clones upon costimulation with anti-CD3/anti-CD28 antibodies.
J. Proteomics 131:190-198(2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-2678
Cell line databases/resources CLO; CLO_0006985
CLO; CLO_0009836
cancercelllines; CVCL_6410
LINCS_LDP; LCL-2038
Biological sample resources BioSample; SAMN03471763
Encyclopedic resources Wikidata; Q54898430
Gene expression databases GEO; GSM827148
Polymorphism and mutation databases Progenetix; CVCL_6410
Proteomic databases PRIDE; PXD002871
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30