| Cell line name |
J.gamma1.WT |
|---|
| Synonyms |
J.gamma1.WT-1; J.gamma1.wt |
|---|
| Accession |
CVCL_6411 |
|---|
| Resource Identification Initiative |
To cite this cell line use: J.gamma1.WT (RRID:CVCL_6411) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 9065; PLCG1.
Transformant: ChEBI; CHEBI:132982; Acridine half-mustard dihydrochloride (6-chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride; Acridine mutagen ICR 191).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
|---|
| Sequence variations |
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Argfs*19 (c.121delG); ClinVar=VCV000009512; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 959; BAX; Simple; p.Glu41Glyfs*33 (c.121dupG); ClinVar=VCV000009511; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; p.Gln345Ter (c.1033C>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6079; INPP5D; Simple; c.1097+1065_1097+1112del47; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 7325; MSH2; Simple; p.Arg711Ter (c.2131C>T); ClinVar=VCV000090903; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11491; SYK; Simple; p.Met34Hisfs*3 (c.98_99insG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_6410 (J.gamma1) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
14Y |
|---|
| Category |
Cancer cell line |
|---|
| STR profile |
Source(s): ATCC=CRL-2679
Markers:| Amelogenin | X |
| CSF1PO | 11,12 |
| D2S1338 | 18,23 |
| D3S1358 | 15,17 |
| D5S818 | 9 |
| D7S820 | 8,12 |
| D8S1179 | 13,14 |
| D13S317 | 8,12 |
| D16S539 | 11 |
| D18S51 | 13,20 |
| D19S433 | 14,15.2 |
| D21S11 | 31.2,35.2 |
| FGA | 20,21 |
| Penta D | 10,13 |
| Penta E | 10,12 |
| TH01 | 6,9.3 |
| TPOX | 8,9,10 |
| vWA | 18,19 |
Run an STR similarity search on this cell line |
|---|
| Publications | PubMed=11094067; DOI=10.1128/mcb.20.24.9149-9161.2000; PMCID=PMC102173
Irvin B.J., Williams B.L., Nilson A.E., Maynor H.O., Abraham R.T.
Pleiotropic contributions of phospholipase C-gamma1 (PLC-gamma1) to T-cell antigen receptor-mediated signaling: reconstitution studies of a PLC-gamma1-deficient Jurkat T-cell line.
Mol. Cell. Biol. 20:9149-9161(2000) |
|---|
| Cross-references |
|---|
| Cell line collections (Providers) |
ATCC; CRL-2679
|
|---|
| Cell line databases/resources |
CLO; CLO_0006986
CLO; CLO_0009837
cancercelllines; CVCL_6411
LINCS_LDP; LCL-2039
|
|---|
| Biological sample resources |
BioSample; SAMN03471764
|
|---|
| Encyclopedic resources |
Wikidata; Q54898431
|
|---|
| Entry history |
|---|
| Entry creation | 04-Apr-2012 |
|---|
| Last entry update | 10-Sep-2024 |
|---|
| Version number | 31 |
|---|
