Cell line name |
LoVo-92 |
Synonyms |
Lovo-92; Lovo 92; Lovo92 |
Accession |
CVCL_5237 |
Resource Identification Initiative |
To cite this cell line use: LoVo-92 (RRID:CVCL_5237) |
Comments |
Population: Caucasian. Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0399 (LoVo) Children:
|
Sex of cell |
Male |
Age at sampling |
56Y |
Category |
Cancer cell line |
Publications | PubMed=8632910 Pocard M., Chevillard S., Villaudy J., Poupon M.-F., Dutrillaux B., Remvikos Y. Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation. Oncogene 12:875-882(1996) PubMed=9989828; DOI=10.1038/sj.onc.1202336 Soulie P., Poupon M.-F., Remvikos Y., Dutrillaux B., Muleris M. Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers. Oncogene 18:775-781(1999) PubMed=17339891; DOI=10.1038/sj.bjc.6603639; PMCID=PMC2360080 Giovannetti E., Backus H.H.J., Wouters D., Ferreira C.G., van Houten V.M.M., Brakenhoff R.H., Poupon M.-F., Azzarello A., Pinedo H.M., Peters G.J. Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br. J. Cancer 96:769-775(2007) PubMed=18600534; DOI=10.1080/15257770802145512 Giovannetti E., Backus H.H.J., Wouters D., Peters G.J. Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells. Nucleosides Nucleotides Nucleic Acids 27:740-745(2008) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_5237
|
Anatomy/cell type resources |
BTO; BTO:0004146
|
Encyclopedic resources |
Wikidata; Q54902900
|
Gene expression databases |
GEO; GSM503149
|
Polymorphism and mutation databases |
Progenetix; CVCL_5237
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 05-Oct-2023 |
Version number | 20 |
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