Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
| Cell line name |
Lovo-143X19 |
|---|
| Synonyms |
143X19 |
|---|
| Accession |
CVCL_6A75 |
|---|
| Resource Identification Initiative |
To cite this cell line use: Lovo-143X19 (RRID:CVCL_6A75) |
|---|
| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53 (Note=With p.Val143Ala).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
|---|
| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Colon adenocarcinoma (NCIt: C4349) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_5237 (LoVo-92) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
56Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=8632910
Pocard M., Chevillard S., Villaudy J., Poupon M.-F., Dutrillaux B., Remvikos Y.
Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation.
Oncogene 12:875-882(1996) PubMed=9989828; DOI=10.1038/sj.onc.1202336
Soulie P., Poupon M.-F., Remvikos Y., Dutrillaux B., Muleris M.
Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers.
Oncogene 18:775-781(1999) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_6A75
|
|---|
| Encyclopedic resources |
Wikidata; Q54902895
|
|---|
| Entry history |
|---|
| Entry creation | 23-Feb-2016 |
|---|
| Last entry update | 10-Sep-2024 |
|---|
| Version number | 15 |
|---|
