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| Cell line name |
Lovo-273X17 |
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| Synonyms |
Lovo273X17; 273X17 |
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| Accession |
CVCL_5236 |
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| Resource Identification Initiative |
To cite this cell line use: Lovo-273X17 (RRID:CVCL_5236) |
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| Comments |
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; 11998; TP53 (Note=With p.Arg273His).
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056. |
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| Sequence variations |
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg1114Ter (c.3340C>T); ClinVar=VCV000236589; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Met1431fs*42 (c.4289delC) (p.T1430fs); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Arg2816Gln (c.8447G>A); ClinVar=VCV000419681; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Cys (c.1513C>T); ClinVar=VCV000069961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6768; SMAD2; Simple; p.Ala292Val (c.875C>T); Zygosity=Heterozygous (from parent cell line).
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_5237 (LoVo-92) |
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| Sex of cell |
Male |
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| Age at sampling |
56Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=8632910
Pocard M., Chevillard S., Villaudy J., Poupon M.-F., Dutrillaux B., Remvikos Y.
Different p53 mutations produce distinct effects on the ability of colon carcinoma cells to become blocked at the G1/S boundary after irradiation.
Oncogene 12:875-882(1996) PubMed=18600534; DOI=10.1080/15257770802145512
Giovannetti E., Backus H.H.J., Wouters D., Peters G.J.
Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells.
Nucleosides Nucleotides Nucleic Acids 27:740-745(2008) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_5236
|
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| Anatomy/cell type resources |
BTO; BTO:0004144
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| Encyclopedic resources |
Wikidata; Q54902898
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Sep-2024 |
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| Version number | 22 |
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