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Cellosaurus EPC (CVCL_4361)

[Text version]
Cell line name EPC
Synonyms Epithelioma Papulosum Cyprini
Accession CVCL_4361
Resource Identification Initiative To cite this cell line use: EPC (RRID:CVCL_4361)
Comments Group: Fish cell line.
Problematic cell line: Misidentified. Originally deposited as a carp (Cyprinus carpio) cell line, is in fact a fathead minnow (Pimephales promelas) cell line (PubMed=20497291).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00302.
Doubling time: ~36 hours (ATCC=CRL-2872).
Cell type: Epithelial cell; CL=CL_0000066.
Species of origin Pimephales promelas (Fathead minnow) (NCBI Taxonomy: 90988)
Hierarchy Children:
CVCL_6E02 (EPCtiHSP70)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Spontaneously immortalized cell line
Web pages https://de.wikipedia.org/wiki/EPC-Zellen

Fijan N., Sulimanovic D., Bearzotti M., Muzinic D., Zwillenberg L.O., Chilmonczyk S., Vautherot J.-F., de Kinkelin P.
Some properties of the Epithelioma papulosum cyprini (EPC) cell line from carp Cyprinus carpio.
Ann. Inst. Pasteur Virol. 134:207-220(1983)

Kimura T., Yoshimizu M., Gorie S.
A new rhabdovirus isolated in Japan from cultured hirame (Japanese flounder) Paralichthys olivaceus and ayu Plecoglossus altivelis.
Dis. Aquat. Organ. 1:209-217(1986)

Yoshimizu M., Kamei M., Dirakbusarakom S., Kimura T.
Fish cell lines: susceptibility to salmonid viruses.
(In) Invertebrate and fish tissue culture; Kuroda Y., Kurstak E., Maramorosch K. (eds.); pp.207-217; Japan Sci. Soc.; Tokyo (1988)

Frerichs G.N., Hill B.J., Way K.
Ulcerative disease rhabdovirus: cell-line susceptibility and serological comparison with other fish rhabdoviruses.
J. Fish Dis. 12:51-56(1989)

Fernandez R.D., Yoshimizu M., Ezura Y., Kimura T.
Comparative growth response of fish cell lines in different media, temperatures, and and sodium chloride concentrations.
Fish Pathol. 28:27-34(1993)

Oh M.-J., Yoshimizu M., Kimura T., Ezura Y.
A new virus isolated from salmonid fish.
Fish Pathol. 30:23-32(1995)

PubMed=11673072; DOI=10.1016/S1383-5718(01)00268-6
Kammann U., Bunke M., Steinhart H., Theobald N.
A permanent fish cell line (EPC) for genotoxicity testing of marine sediments with the comet assay.
Mutat. Res. 498:67-77(2001)

Bols N.C., Dayeh V.R., Lee L.E.J., Schirmer K.
Use of fish cell lines in the toxicology and ecotoxicology of fish Piscine cell lines in environmental toxicology.
(In) Biochemistry and molecular biology of fishes, Vol. 6; Mommsen T.P., Moon T.W. (eds.); pp.43-84; Elsevier; Amsterdam (2005)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

PubMed=20497291; DOI=10.1111/j.1365-2761.2010.01165.x
Winton J.R., Batts W.N., de Kinkelin P., LeBerre M., Bremont M., Fijan N.
Current lineages of the epithelioma papulosum cyprini (EPC) cell line are contaminated with fathead minnow, Pimephales promelas, cells.
J. Fish Dis. 33:701-704(2010)

PubMed=33053677; DOI=10.3390/pathogens9100833
Pham P.H., Misk E., Papazotos F., Jones G., Polinski M.P., Contador E., Russell S., Garver K.A., Lumsden J.S., Bols N.C.
Screening of fish cell lines for piscine orthoreovirus-1 (PRV-1) amplification: identification of the non-supportive PRV-1 invitrome.
Pathogens 9:833.1-833.25(2020)

PubMed=34382581; DOI=10.3354/dao03615
Ito T., Kamaishi T.
Japanese amberjack Seriola quinqueradiata and red sea bream Pagrus major susceptibility to infectious hematopoietic necrosis virus (IHNV) isolate.
Dis. Aquat. Organ. 146:1-8(2021)

Cell line collections (Providers) ATCC; CRL-2872
ECACC; 93120820
Cell line databases/resources CLO; CLO_0002940
CLDB; cl1167
CLDB; cl1168
Biological sample resources BioSample; SAMN03152008
Encyclopedic resources Wikidata; Q26882920
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25