AC   CVCL_4361
SY   Epithelioma Papulosum Cyprini
DR   CLO; CLO_0002940
DR   CLDB; cl1167
DR   CLDB; cl1168
DR   ATCC; CRL-2872
DR   BioSample; SAMN03152008
DR   ECACC; 93120820
DR   Wikidata; Q26882920
RX   CelloPub=CLPUB00103;
RX   DOI=10.1016/S0769-2617(83)80060-4;
RX   DOI=10.1016/S1873-0140(05)80005-0;
RX   DOI=10.1111/j.1365-2761.1989.tb01290.x;
RX   DOI=10.3147/jsfp.28.27;
RX   DOI=10.3147/jsfp.30.23;
RX   DOI=10.3354/dao001209;
RX   PubMed=11673072;
RX   PubMed=20143388;
RX   PubMed=20497291;
RX   PubMed=33053677;
RX   PubMed=34382581;
CC   Group: Fish cell line.
CC   Problematic cell line: Misidentified. Originally deposited as a carp (Cyprinus carpio) cell line, is in fact a fathead minnow (Pimephales promelas) cell line (PubMed=20497291).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00302.
CC   Doubling time: ~36 hours (ATCC=CRL-2872).
CC   Derived from sampling site: Cell type=Epithelial cell.
OX   NCBI_TaxID=90988; ! Pimephales promelas (Fathead minnow)
SX   Sex unspecified
CA   Spontaneously immortalized cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 23
RX   CelloPub=CLPUB00103;
RA   Yoshimizu M., Kamei M., Dirakbusarakom S., Kimura T.;
RT   "Fish cell lines: susceptibility to salmonid viruses.";
RL   (In) Invertebrate and fish tissue culture; Kuroda Y., Kurstak E., Maramorosch K. (eds.); pp.207-217; Japan Sci. Soc.; Tokyo (1988).
RX   DOI=10.1016/S0769-2617(83)80060-4;
RA   Fijan N., Sulimanovic D., Bearzotti M., Muzinic D., Zwillenberg L.O.,
RA   Chilmonczyk S., Vautherot J.-F., de Kinkelin P.;
RT   "Some properties of the Epithelioma papulosum cyprini (EPC) cell line
RT   from carp Cyprinus carpio.";
RL   Ann. Inst. Pasteur Virol. 134:207-220(1983).
RX   DOI=10.1016/S1873-0140(05)80005-0;
RA   Bols N.C., Dayeh V.R., Lee L.E.J., Schirmer K.;
RT   "Use of fish cell lines in the toxicology and ecotoxicology of fish.
RT   Piscine cell lines in environmental toxicology.";
RL   (In) Biochemistry and molecular biology of fishes, Vol. 6; Mommsen T.P., Moon T.W. (eds.); pp.43-84; Elsevier; Amsterdam (2005).
RX   DOI=10.1111/j.1365-2761.1989.tb01290.x;
RA   Frerichs G.N., Hill B.J., Way K.;
RT   "Ulcerative disease rhabdovirus: cell-line susceptibility and
RT   serological comparison with other fish rhabdoviruses.";
RL   J. Fish Dis. 12:51-56(1989).
RX   DOI=10.3147/jsfp.28.27;
RA   Fernandez R.D., Yoshimizu M., Ezura Y., Kimura T.;
RT   "Comparative growth response of fish cell lines in different media,
RT   temperatures, and and sodium chloride concentrations.";
RL   Fish Pathol. 28:27-34(1993).
RX   DOI=10.3147/jsfp.30.23;
RA   Oh M.-J., Yoshimizu M., Kimura T., Ezura Y.;
RT   "A new virus isolated from salmonid fish.";
RL   Fish Pathol. 30:23-32(1995).
RX   DOI=10.3354/dao001209;
RA   Kimura T., Yoshimizu M., Gorie S.;
RT   "A new rhabdovirus isolated in Japan from cultured hirame (Japanese
RT   flounder) Paralichthys olivaceus and ayu Plecoglossus altivelis.";
RL   Dis. Aquat. Organ. 1:209-217(1986).
RX   PubMed=11673072; DOI=10.1016/S1383-5718(01)00268-6;
RA   Kammann U., Bunke M., Steinhart H., Theobald N.;
RT   "A permanent fish cell line (EPC) for genotoxicity testing of marine
RT   sediments with the comet assay.";
RL   Mutat. Res. 498:67-77(2001).
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
RX   PubMed=20497291; DOI=10.1111/j.1365-2761.2010.01165.x;
RA   Winton J.R., Batts W.N., de Kinkelin P., LeBerre M., Bremont M.,
RA   Fijan N.;
RT   "Current lineages of the epithelioma papulosum cyprini (EPC) cell line
RT   are contaminated with fathead minnow, Pimephales promelas, cells.";
RL   J. Fish Dis. 33:701-704(2010).
RX   PubMed=33053677; DOI=10.3390/pathogens9100833;
RA   Pham P.H., Misk E., Papazotos F., Jones G., Polinski M.P.,
RA   Contador E., Russell S., Garver K.A., Lumsden J.S., Bols N.C.;
RT   "Screening of fish cell lines for piscine orthoreovirus-1 (PRV-1)
RT   amplification: identification of the non-supportive PRV-1 invitrome.";
RL   Pathogens 9:833.1-833.25(2020).
RX   PubMed=34382581; DOI=10.3354/dao03615;
RA   Ito T., Kamaishi T.;
RT   "Japanese amberjack Seriola quinqueradiata and red sea bream Pagrus
RT   major susceptibility to infectious hematopoietic necrosis virus (IHNV)
RT   isolate.";
RL   Dis. Aquat. Organ. 146:1-8(2021).