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Cellosaurus KHOS/NP (CVCL_2546)

[Text version]
Cell line name KHOS/NP
Synonyms KHOS-NP; KHOS NP; KHOSNP; R-970-5; KHOS
Accession CVCL_2546
Resource Identification Initiative To cite this cell line use: KHOS/NP (RRID:CVCL_2546)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Characteristics: Tumorigenic.
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0439 (MNNG/HOS Cl #5)
Children:
CVCL_T431 (KH OS R1)CVCL_2544 (KHOS-240S)CVCL_2545 (KHOS-312H)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1544; CLS=300235; ECACC=84102903

Markers:
AmelogeninX
CSF1PO12
D2S133824
D3S135815
D5S81813
D7S82011,12
D8S117911,14
D13S31712
D16S53910,13
D18S5114,17 (ATCC=CRL-1544)
17 (CLS=300235)
D19S43313
D21S1131.2,32.2
FGA24
Penta D9,10
Penta E7,12
TH016
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=2978869
Ehrhart J.-C., Duthu A., Ullrich S., Appella E., May P.
Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.
Oncogene 3:595-603(1988)

PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990; PMCID=PMC361354
Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
p53 functions as a cell cycle control protein in osteosarcomas.
Mol. Cell. Biol. 10:5772-5781(1990)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-1544
ATCC; CRL-7723 - Discontinued
CLS; 300235
ECACC; 84102903
IZSLER; BS TCL 80
Cell line databases/resources CLO; CLO_0007096
CLO; CLO_0007097
CLO; CLO_0008725
CLDB; cl3030
CLDB; cl3031
cancercelllines; CVCL_2546
LINCS_LDP; LCL-1425
Anatomy/cell type resources BTO; BTO:0003922
Chemistry resources ChEMBL-Cells; CHEMBL3308001
ChEMBL-Targets; CHEMBL612598
PubChem_Cell_line; CVCL_2546
Encyclopedic resources Wikidata; Q54899911
Gene expression databases GEO; GSM186428
GEO; GSM186429
GEO; GSM827385
GEO; GSM1676341
GEO; GSM1701672
Polymorphism and mutation databases Cosmic; 1044083
Cosmic; 1074393
Progenetix; CVCL_2546
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30