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Cellosaurus KHOS-240S (CVCL_2544)

[Text version]
Cell line name KHOS-240S
Synonyms KHOS240S; 240S
Accession CVCL_2544
Resource Identification Initiative To cite this cell line use: KHOS-240S (RRID:CVCL_2544)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2546 (KHOS/NP)
Children:
CVCL_A9AN (HOS-SL)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; ECACC

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81813
D7S82011,12
D8S117911,14
D13S31712
D16S53910,13
D18S5114,17
D21S1131.2,32.2
FGA24
Penta D9,10
Penta E7,12
TH016
TPOX11
vWA18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=62397; DOI=10.1126/science.62397
Cho H.Y., Cutchins E.C., Rhim J.S., Huebner R.J.
Revertants of human cells transformed by murine sarcoma virus.
Science 194:951-953(1976)

PubMed=2978869
Ehrhart J.-C., Duthu A., Ullrich S., Appella E., May P.
Specific interaction between a subset of the p53 protein family and heat shock proteins hsp72/hsc73 in a human osteosarcoma cell line.
Oncogene 3:595-603(1988)

PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990
Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
p53 functions as a cell cycle control protein in osteosarcomas.
Mol. Cell. Biol. 10:5772-5781(1990)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-1545
CCTCC; GDC0254
CLS; 300433
ECACC; 86112810
Cell line databases/resources CLO; CLO_0007098
CLDB; cl3028
cancercelllines; CVCL_2544
IGRhCellID; KHOS240S
LINCS_LDP; LCL-1426
Anatomy/cell type resources BTO; BTO:0003923
Encyclopedic resources Wikidata; Q54899909
Experimental variables resources EFO; EFO_0002219
Gene expression databases ArrayExpress; E-MTAB-38
GEO; GSM186426
GEO; GSM186427
GEO; GSM827381
GEO; GSM1676358
GEO; GSM1701688
Polymorphism and mutation databases Cosmic; 1074392
Progenetix; CVCL_2544
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27