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Cellosaurus KHOS-312H (CVCL_2545)

[Text version]
Cell line name KHOS-312H
Synonyms KHOS312H
Accession CVCL_2545
Resource Identification Initiative To cite this cell line use: KHOS-312H (RRID:CVCL_2545)
Comments Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Transformant: NCBI_TaxID; 11808; Kirsten murine sarcoma virus (Ki-MSV).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Misspelling: KHOS-321H; Note=Due to an error in some ATCC catalogs, this cell line has been referred to as KHOS-321H by ATCC and in the literature.
Misspelling: KHOS321H; Note=Due to an error in some ATCC catalogs.
Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2546 (KHOS/NP)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-1546; CLS=300447; ECACC=86112811

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81813
D7S82011,12
D8S117911,14
D13S31712
D16S53910,13
D18S5114,17
D21S1131.2,32.2
FGA24
Penta D9,10
Penta E7,12
TH016
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=62397; DOI=10.1126/science.62397
Cho H.Y., Cutchins E.C., Rhim J.S., Huebner R.J.
Revertants of human cells transformed by murine sarcoma virus.
Science 194:951-953(1976)

PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990; PMCID=PMC361354
Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
p53 functions as a cell cycle control protein in osteosarcomas.
Mol. Cell. Biol. 10:5772-5781(1990)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) ATCC; CRL-1546
CLS; 300447
ECACC; 86112811
Cell line databases/resources CLO; CLO_0007099
CLO; CLO_0007100
CLDB; cl3029
cancercelllines; CVCL_2545
LINCS_LDP; LCL-1427
Anatomy/cell type resources BTO; BTO:0003924
Chemistry resources ChEMBL-Cells; CHEMBL3308382
ChEMBL-Targets; CHEMBL614591
PubChem_Cell_line; CVCL_2545
Encyclopedic resources Wikidata; Q54899910
Gene expression databases GEO; GSM827383
GEO; GSM1676359
GEO; GSM1701689
Polymorphism and mutation databases Cosmic; 1074400
Progenetix; CVCL_2545
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number30