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Cellosaurus HMT-3522 S2 (CVCL_2500)

[Text version]
Cell line name HMT-3522 S2
Synonyms HMT-3522-S2; HMT-3522S2; HMT3522S2; S2; S-2; HMT-3522/gt-1; gt-1; HMT-3522/growth-transformed-1
Accession CVCL_2500
Resource Identification Initiative To cite this cell line use: HMT-3522 S2 (RRID:CVCL_2500)
Comments Population: Caucasian.
Characteristics: Established from parent cell line by permanent ommission of EGF in culture medium.
Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (PubMed=7982476).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6855 (HMT-3522)
CVCL_2501 (HMT-3522 T4-2)
Sex of cell Female
Age at sampling 50Y
Category Spontaneously immortalized cell line
STR profile Source(s): ECACC=98102211


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PubMed=7982476; DOI=10.1006/excr.1994.1355
Moyret C., Madsen M.W., Cooke J., Briand P., Theillet C.
Gradual selection of a cellular clone presenting a mutation at codon 179 of the p53 gene during establishment of the immortalized human breast epithelial cell line HMT-3522.
Exp. Cell Res. 215:380-385(1994)

Briand P., Nielsen K.V., Madsen M.W., Petersen O.W.
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
Cancer Res. 56:2039-2044(1996)

PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225
Rizki A., Weaver V.M., Lee S.-Y., Rozenberg G.I., Chin K., Myers C.A., Bascom J.L., Mott J.D., Semeiks J.R., Grate L.R., Mian I.S., Borowsky A.D., Jensen R.A., Idowu M.O., Chen F.-Q., Chen D.J., Petersen O.W., Gray J.W., Bissell M.J.
A human breast cell model of preinvasive to invasive transition.
Cancer Res. 68:1378-1387(2008)

Cell line collections (Providers) ECACC; 98102211
Cell line databases/resources cancercelllines; CVCL_2500
Encyclopedic resources Wikidata; Q54889969
Polymorphism and mutation databases Cosmic; 889086
Cosmic; 1066170
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number18