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Cellosaurus HMT-3522 T4-2 (CVCL_2501)

[Text version]
Cell line name HMT-3522 T4-2
Synonyms T4-2; T4; HMT-3522/mt-1; mt-1; HMT-3522/massive tumor-1
Accession CVCL_2501
Resource Identification Initiative To cite this cell line use: HMT-3522 T4-2 (RRID:CVCL_2501)
Comments Part of: GrayJW breast cancer cell line panel.
Population: Caucasian.
Doubling time: 32.94 hours (GrayJW panel).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Donor information: Established from a nontumorigenic fibrocystic breast lesion (from parent cell line).
Derived from site: In situ; Breast, epithelium; UBERON=UBERON_0008359.
Cell type: Epithelial cell of mammary gland; CL=CL_0002327.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.His179Asn (c.535C>A); ClinVar=VCV000376609; Zygosity=Unspecified (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2500 (HMT-3522 S2)
Sex of cell Female
Age at sampling 50Y
Category Spontaneously immortalized cell line
STR profile Source(s): ECACC


Run an STR similarity search on this cell line
Web pages https://www.synapse.org/#!Synapse:syn2346643/wiki/62255

Briand P., Nielsen K.V., Madsen M.W., Petersen O.W.
Trisomy 7p and malignant transformation of human breast epithelial cells following epidermal growth factor withdrawal.
Cancer Res. 56:2039-2044(1996)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004
Kenny P.A., Lee G.Y., Myers C.A., Neve R.M., Semeiks J.R., Spellman P.T., Lorenz K., Lee E.H., Barcellos-Hoff M.H., Petersen O.W., Gray J.W., Bissell M.J.
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=18316601; DOI=10.1158/0008-5472.CAN-07-2225
Rizki A., Weaver V.M., Lee S.-Y., Rozenberg G.I., Chin K., Myers C.A., Bascom J.L., Mott J.D., Semeiks J.R., Grate L.R., Mian I.S., Borowsky A.D., Jensen R.A., Idowu M.O., Chen F.-Q., Chen D.J., Petersen O.W., Gray J.W., Bissell M.J.
A human breast cell model of preinvasive to invasive transition.
Cancer Res. 68:1378-1387(2008)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110
Daemen A., Griffith O.L., Heiser L.M., Wang N.J., Enache O.M., Sanborn Z., Pepin F., Durinck S., Korkola J.E., Griffith M., Hur J.S., Huh N., Chung J., Cope L., Fackler M.J., Umbricht C.B., Sukumar S., Seth P., Sukhatme V.P., Jakkula L.R., Lu Y.-L., Mills G.B., Cho R.J., Collisson E.A., van 't Veer L.J., Spellman P.T., Gray J.W.
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

Cell line collections (Providers) ECACC; 98102212
Cell line databases/resources cancercelllines; CVCL_2501
LINCS_HMS; 51123
Anatomy/cell type resources BTO; BTO:0006210
Chemistry resources PharmacoDB; T4_1558_2019
Encyclopedic resources Wikidata; Q54889970
Gene expression databases ArrayExpress; E-TABM-244
GEO; GSM1172999
GEO; GSM1219379
GEO; GSM1219380
GEO; GSM1219381
GEO; GSM1219382
GEO; GSM1219383
GEO; GSM1219384
GEO; GSM1219385
GEO; GSM1219386
GEO; GSM1219387
GEO; GSM1219388
GEO; GSM1219389
GEO; GSM1219390
GEO; GSM1219391
GEO; GSM1219392
GEO; GSM1219393
GEO; GSM1219394
GEO; GSM1219395
GEO; GSM1219396
GEO; GSM1219397
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18