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Cellosaurus HROC32 (CVCL_1D06)

[Text version]
Cell line name HROC32
Synonyms HROC32P
Accession CVCL_1D06
Resource Identification Initiative To cite this cell line use: HROC32 (RRID:CVCL_1D06)
Comments From: Linnebacher, Michael; University of Rostock; Rostock; Germany.
Population: Caucasian.
Doubling time: 32 +- 10.6 hours (PubMed=25574089); 30 hours (CLS=300818).
Microsatellite instability: Stable (MSS) (PubMed=25926053).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Ala (c.35G>C); ClinVar=VCV000045122; Zygosity=Unspecified (CLS=300818).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (CLS=300818).
HLA typing Source: CLS=300818
Class I
HLA-AA*01:01,02:01
HLA-BB*08:01,03:01
HLA-CC*07:01,14:02
Class II
HLA-DPDPB1*01:01,02:01
HLA-DQDQA1*01:02,05:01
DQB1*02:01,03:01
HLA-DRDRB1*03:01,11:01
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_YD55 ! B-LCL-HROC32
CVCL_1D07 ! HROC32 T3 M1
Sex of cell Female
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): CLS=300818; Direct_author_submission; PubMed=25926053

Markers:
AmelogeninX
CSF1PO14
D3S135815,17
D5S81811,12 (CLS=300818; Direct_author_submission)
12 (PubMed=25926053)
D7S8208,11
D8S117912
D13S31711,12 (Direct_author_submission)
12 (CLS=300818; PubMed=25926053)
D16S53911,12
D18S5112
D21S1131
FGA18,19
Penta D12
Penta E10
TH018,9
TPOX8,11
vWA19

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Publications

PubMed=25574089; DOI=10.3748/wjg.v21.i1.164; PMCID=PMC4284332
Maletzki C., Gock M., Randow M., Klar E., Huhns M., Prall F., Linnebacher M.
Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
World J. Gastroenterol. 21:164-176(2015)

PubMed=25926053; DOI=10.1038/ncomms8002
Medico E., Russo M., Picco G., Cancelliere C., Valtorta E., Corti G., Buscarino M., Isella C., Lamba S., Martinoglio B., Veronese S., Siena S., Sartore-Bianchi A., Beccuti M., Mottolese M., Linnebacher M., Cordero F., Di Nicolantonio F., Bardelli A.
The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets.
Nat. Commun. 6:7002.1-7002.10(2015)

PubMed=31601052; DOI=10.3390/cancers11101520; PMCID=PMC6826890
Mullins C.S., Micheel B., Matschos S., Leuchter M., Burtin F., Krohn M., Huhns M., Klar E., Prall F., Linnebacher M.
Integrated biobanking and tumor model establishment of human colorectal carcinoma provides excellent tools for preclinical research.
Cancers (Basel) 11:1520.1-1520.18(2019)

Cross-references
Cell line collections (Providers) CLS; 300818
Cell line databases/resources cancercelllines; CVCL_1D06
Encyclopedic resources Wikidata; Q54895282
Gene expression databases GEO; GSM1448079
Polymorphism and mutation databases Cosmic; 2324290
Entry history
Entry creation08-Jul-2015
Last entry update10-Apr-2025
Version number24