Cellosaurus cell line SH-EP (CVCL

Cellosaurus SH-EP (CVCL_0524)

[Text version]

Cell line name

SH-EP

Synonyms

SHEP

Accession

CVCL_0524

Resource Identification Initiative

To cite this cell line use: SH-EP (RRID:CVCL_0524)

Comments

Population: Caucasian.
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.

Sequence variations

Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).

Disease

Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0531 (SK-N-SH)
Children:

CVCL_VL18 (MYCN-2 Tet-on)	CVCL_VL19 (MYCN-3 Tet-on)	CVCL_0522 (SH-EP007)
CVCL_0F47 (SH-EP1)	CVCL_2A38 (SHEP-SF)	CVCL_EI12 (SHEP-TR-miR-17-92)
CVCL_RR78 (SHEPrCDDP1000)	CVCL_RS82 (SHEPrDOX100)	CVCL_RR79 (SHEPrETO100)
CVCL_RS18 (SHEPrSNS-032_2000nM)	CVCL_RR80 (SHEPrVCR1)	CVCL_RS83 (SHEPrVCR10)
CVCL_RS84 (SHEPrVCR20)

Sex of cell

Female

Age at sampling

Category

Cancer cell line

Web pages

https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/s/cell-lines-detail-530.html

Publications

PubMed=6137586; DOI=10.1093/jnci/71.4.741
Ross R.A., Spengler B.A., Biedler J.L.
Coordinate morphological and biochemical interconversion of human neuroblastoma cells.
J. Natl. Cancer Inst. 71:741-747(1983)

PubMed=2535691
Ciccarone V.C., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.
Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.
Cancer Res. 49:219-225(1989)

PubMed=1354203; DOI=10.1002/ijc.2910520116
Gross N., Favre S., Beck D., Meyer M.
Differentiation-related expression of adhesion molecules and receptors on human neuroblastoma tissues, cell lines and variants.
Int. J. Cancer 52:85-91(1992)

PubMed=24466371; DOI=10.1593/tlo.13544; PMCID=PMC3890703
Loschmann N., Michaelis M., Rothweiler F., Zehner R., Cinatl J., Voges Y., Sharifi M., Riecken K., Meyer J., von Deimling A., Fichtner I., Ghafourian T., Westermann F., Cinatl J. Jr.
Testing of SNS-032 in a panel of human neuroblastoma cell lines with acquired resistance to a broad range of drugs.
Transl. Oncol. 6:685-696(2013)

PubMed=27517323; DOI=10.18632/oncotarget.11160; PMCID=PMC5295411
Loschmann N., Michaelis M., Rothweiler F., Voges Y., Balonova B., Blight B.A., Cinatl J. Jr.
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

Cross-references

Cell line databases/resources

MCCL; MCC:0000423
cancercelllines; CVCL_0524

Anatomy/cell type resources

BTO; BTO:0005397

Encyclopedic resources

Wikidata; Q54953212

Experimental variables resources

EFO; EFO_0006294

Gene expression databases

GEO; GSM1622295

Polymorphism and mutation databases