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Cellosaurus SHEPrSNS-032_2000nM (CVCL_RS18)

[Text version]
Cell line name SHEPrSNS-032_2000nM
Synonyms SHEPrSNS-032(2000nM)
Accession CVCL_RS18
Resource Identification Initiative To cite this cell line use: SHEPrSNS-032_2000nM (RRID:CVCL_RS18)
Comments Part of: Resistant Cancer Cell Line (RCCL) collection.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:91399; N-[5-[(5-tert-butyl-2-oxazolyl)methylthio]-2-thiazolyl]-4-piperidinecarboxamide (SNS-032; BMS-387032).
Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
Sequence variations
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Neuroblastoma (NCIt: C3270)
Neuroblastoma (ORDO: Orphanet_635)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0524 (SH-EP)
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
Web pages https://www.wass-michaelislab.org/rccl.php

PubMed=27517323; DOI=10.18632/oncotarget.11160
Loschmann N., Michaelis M., Rothweiler F., Voges Y., Balonova B., Blight B.A., Cinatl J. Jr.
ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance.
Oncotarget 7:58051-58064(2016)

Cell line databases/resources cancercelllines; CVCL_RS18
Encyclopedic resources Wikidata; Q54953308
Entry history
Entry creation05-Mar-2018
Last entry update05-Oct-2023
Version number8