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Cellosaurus NCI-H295 (CVCL_0456)

[Text version]
Cell line name NCI-H295
Synonyms H295; H-295; NCI-H-295
Accession CVCL_0456
Resource Identification Initiative To cite this cell line use: NCI-H295 (RRID:CVCL_0456)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-10296.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (ATCC=CRL-10296).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_0457 (NCI-H295A)CVCL_0458 (NCI-H295R)CVCL_S901 (NCI-H295R-S2)
CVCL_S902 (NCI-H295R-S3)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-10296

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8209,12
D13S31713
D16S53911
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/n/cell-lines-detail-402.html
Publications

PubMed=2386954
Gazdar A.F., Oie H.K., Shackleton C.H., Chen T.-R., Triche T.J., Myers C.E., Chrousos G.P., Brennan M.F., Stein C.A., La Rocca R.V.
Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis.
Cancer Res. 50:5488-5496(1990)

PubMed=8404594; DOI=10.1210/endo.133.4.8404594
Bird I.M., Hanley N.A., Word R.A., Mathis J.M., McCarthy J.L., Mason J.I., Rainey W.E.
Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion.
Endocrinology 133:1555-1561(1993)

PubMed=8056157; DOI=10.1016/0303-7207(94)90277-1
Rainey W.E., Bird I.M., Mason J.I.
The NCI-H295 cell line: a pluripotent model for human adrenocortical studies.
Mol. Cell. Endocrinol. 100:45-50(1994)

PubMed=8806089; DOI=10.1002/jcb.240630502
Gazdar A.F., Minna J.D.
NCI series of cell lines: an historical perspective.
J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

PubMed=8806092; DOI=10.1002/jcb.240630505
Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
NCI-Navy Medical Oncology Branch cell line data base.
J. Cell. Biochem. Suppl. 24:32-91(1996)

Patent=US5792657
Gazdar A.F., La Rocca R.V., Stein C.A., Myers C.E., Oie H.K.
Steroid secreting human adrenocortical carcinoma cell lines.
Patent number US5792657, 11-Aug-1998

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
Rainey W.E., Saner K., Schimmer B.P.
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041; PMCID=PMC3288152
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019; PMCID=PMC4269336
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w; PMCID=PMC9385758
Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R., Hantel C.
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-10296 - Discontinued
BCRC; 60354
Cell line databases/resources CLO; CLO_0008081
MCCL; MCC:0000502
cancercelllines; CVCL_0456
TOKU-E; 2687
Anatomy/cell type resources BTO; BTO_0002587
Biological sample resources BioSample; SAMN03471298
Encyclopedic resources Wikidata; Q28226675
Gene expression databases ArrayExpress; E-MTAB-783
Polymorphism and mutation databases Cosmic; 684682
Cosmic; 908466
Cosmic; 1179076
Cosmic; 2239455
Cosmic; 2364100
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number30