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Cellosaurus NCI-H295A (CVCL_0457)

[Text version]
Cell line name NCI-H295A
Synonyms H295A; H-295A
Accession CVCL_0457
Resource Identification Initiative To cite this cell line use: NCI-H295A (RRID:CVCL_0457)
Comments Characteristics: Grows as monolayer.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0456 (NCI-H295)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=9024219; DOI=10.1210/jcem.82.2.3721
Rodriguez H., Hum D.W., Staels B., Miller W.L.
Transcription of the human genes for cytochrome P450scc and P450c17 is regulated differently in human adrenal NCI-H295 cells than in mouse adrenal Y1 cells.
J. Clin. Endocrinol. Metab. 82:365-371(1997)

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
Rainey W.E., Saner K., Schimmer B.P.
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=18000308; DOI=10.1677/JOE-07-0166
Samandari E., Kempna P., Nuoffer J.-M., Hofer G., Mullis P.-E., Fluck C.E.
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.
J. Endocrinol. 195:459-472(2007)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041; PMCID=PMC3288152
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019; PMCID=PMC4269336
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

Cross-references
Cell line databases/resources MCCL; MCC:0000354
cancercelllines; CVCL_0457
Anatomy/cell type resources BTO; BTO:0005669
Encyclopedic resources Wikidata; Q54908017
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number17