• Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
  

PubMed=15541570; DOI=10.1016/j.mce.2003.12.020
Rainey W.E., Saner K., Schimmer B.P.
Adrenocortical cell lines.
Mol. Cell. Endocrinol. 228:23-38(2004)

PubMed=18000308; DOI=10.1677/JOE-07-0166
Samandari E., Kempna P., Nuoffer J.-M., Hofer G., Mullis P.-E., Fluck C.E.
Human adrenal corticocarcinoma NCI-H295R cells produce more androgens than NCI-H295A cells and differ in 3beta-hydroxysteroid dehydrogenase type 2 and 17,20 lyase activities.
J. Endocrinol. 195:459-472(2007)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041; PMCID=PMC3288152
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019; PMCID=PMC4269336
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=23951072; DOI=10.1371/journal.pone.0071022; PMCID=PMC3738630
Nishi H., Arai H., Momiyama T.
NCI-H295R, a human adrenal cortex-derived cell line, expresses purinergic receptors linked to Ca(2)(+)-mobilization/influx and cortisol secretion.
PLoS ONE 8:E71022-E71022(2013)

PubMed=29371329; DOI=10.1530/ERC-17-0447; PMCID=PMC5831504
Kiseljak-Vassiliades K., Zhang Y., Bagby S.M., Kar A., Pozdeyev N., Xu M., Gowan K., Sharma V., Raeburn C.D., Albuja-Cruz M.B., Jones K.L., Fishbein L., Schweppe R.E., Somerset H., Pitts T.M., Leong S., Wierman M.E.
Development of new preclinical models to advance adrenocortical carcinoma research.
Endocr. Relat. Cancer 25:437-451(2018)

PubMed=33981288; DOI=10.3389/fendo.2021.669426; PMCID=PMC8108132
Rossini E., Tamburello M., Abate A., Beretta S., Fragni M., Cominelli M., Cosentini D., Hantel C., Bono F., Grisanti S., Poliani P.L., Tiberio G.A.M., Memo M., Sigala S., Berruti A.
Cytotoxic effect of progesterone, tamoxifen and their combination in experimental cell models of human adrenocortical cancer.
Front. Endocrinol. 12:669426.1-669426.13(2021)

PubMed=34572026; DOI=10.3390/cells10092376; PMCID=PMC8466536
Wellman K., Fu R., Baldwin A., Rege J., Murphy E., Rainey W.E., Mukherjee N.
Transcriptomic response dynamics of human primary and immortalized adrenocortical cells to steroidogenic stimuli.
Cells 10:2376.1-2376.15(2021)

PubMed=35563746; DOI=10.3390/cells11091439; PMCID=PMC9103477
Sigala S., Bothou C., Penton D., Abate A., Peitzsch M., Cosentini D., Tiberio G.A.M., Bornstein S.R., Berruti A., Hantel C.
A comprehensive investigation of steroidogenic signaling in classical and new experimental cell models of adrenocortical carcinoma.
Cells 11:1439.1-1439.17(2022)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w; PMCID=PMC9385758
Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R., Hantel C.
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)