Molecular Cytogenetics of Common Epithelial Cancers > Colon Carcinoma cell lines > LS411

LS411   [Cellosaurus entry CVCL_1385]

Colon Cancer Cell Line


Microsatellite-unstable line.

Notable Features

Shows both chromosomal and microsatellite instability. Although microsatellite-unstable, shows typical chromosome instability in the sense that it has a near-triploid, extensively rearranged karyotype, typical of a large group of microsatellite-stable lines (e.g. HT29) [see ref 1 of colon cell line page].

Representative SKY Karyotype

73 (70–76), X, der(X)dup(X)t(X;5), Yx0, 1x3, del(1), 2x3, 3x3, del(3), 4x3, 5x3, del(5), 6x2, 7x2, dup(7), der(7)dup(7)t(7;12), 8x3, der(?)t(8;22), 9x3, del(9), 10x3, 11x3, 12x3, del(12), 13x2, i(13)(q10), 14x1, i(14)(q10), 15x3, 16x3, 17x3, del(17), 18x2, del(18), 19x3, dup(19)(p?), 20x3, 21x1, der(?)t(12;21), 22x2, der(?)t(6;22)[8]/idem, -del(1), +del(6), +der(?)t(10, 17), -dup(19)[3]/idem, -del(1), -der(?)t(6;22), +dup(6), +der(6)t(5;6), +del(11)(q?)[3]



Colon Cancer Cell Lines